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The Resource A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems, edited by Vishwesh V. Kulkarni, Guy-Bart Stan, Karthik Raman, (electronic resource)

A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems, edited by Vishwesh V. Kulkarni, Guy-Bart Stan, Karthik Raman, (electronic resource)

Label
A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems
Title
A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems
Statement of responsibility
edited by Vishwesh V. Kulkarni, Guy-Bart Stan, Karthik Raman
Creator
Contributor
Editor
Provider
Subject
Language
eng
Summary
The complexity of biological systems has intrigued scientists from many disciplines and has given birth to the highly influential field of systems biology wherein a wide array of mathematical techniques, such as flux balance analysis, and technology platforms, such as next generation sequencing, is used to understand, elucidate, and predict the functions of complex biological systems. More recently, the field of synthetic biology, i.e., de novo engineering of biological systems, has emerged. Scientists from various fields are focusing on how to render this engineering process more predictable, reliable, scalable, affordable, and easy. Systems and control theory is a branch of engineering and applied sciences that rigorously deals with the complexities and uncertainties of interconnected systems with the objective of characterising fundamental systemic properties such as stability, robustness, communication capacity, and other performance metrics. Systems and control theory also strives to offer concepts and methods that facilitate the design of systems with rigorous guarantees on these properties. Over the last 100 years, it has made stellar theoretical and technological contributions in diverse fields such as aerospace, telecommunication, storage, automotive, power systems, and others. Can it have, or evolve to have, a similar impact in biology? The chapters in this book demonstrate that, indeed, systems and control theoretic concepts and techniques can have a significant impact in systems and synthetic biology. Volume II contains chapters contributed by leading researchers in the field of systems and synthetic biology that concern modeling physiological processes and bottom-up constructions of scalable biological systems. The modeling problems include characterisation and synthesis of memory, understanding how homoeostasis is maintained in the face of shocks and relatively gradual perturbations, understanding the functioning and robustness of biological clocks such as those at the core of circadian rhythms, and understanding how the cell cycles can be regulated, among others. Some of the bottom-up construction problems investigated in Volume II are as follows: How should biomacromolecules, platforms, and scalable architectures be chosen and synthesised in order to build programmable de novo biological systems? What are the types of constrained optimisation problems encountered in this process and how can these be solved efficiently? As the eminent computer scientist Donald Knuth put it, "biology easily has 500 years of exciting problems to work on". This edited book presents but a small fraction of those for the benefit of (1) systems and control theorists interested in molecular and cellular biology and (2) biologists interested in rigorous modelling, analysis and control of biological systems
http://library.link/vocab/creatorName
Kulkarni, Vishwesh V
Image bit depth
0
LC call number
R-RZ
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
  • Stan, Guy-Bart.
  • Raman, Karthik.
  • SpringerLink
http://library.link/vocab/subjectName
  • Medicine
  • Pharmaceutical technology
  • Bioinformatics
  • Biological models
  • Engineering mathematics
  • Biomedicine
  • Biomedicine general
  • Appl.Mathematics/Computational Methods of Engineering
  • Computational Biology/Bioinformatics
  • Systems Biology
  • Mathematical and Computational Biology
  • Pharmaceutical Sciences/Technology
Label
A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems, edited by Vishwesh V. Kulkarni, Guy-Bart Stan, Karthik Raman, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
1 Network Biomarker Construction for Molecular Investigation and Diagnosis of Lung Cancervia Microarray Data -- 2 The Impact of Next Generation Sequencing Technology on Bacterial Genomics -- 3 Sensitivity Analysis of Circadian Entrainment in the Space of Phase Response Curves -- 4 Modelling and Analysis of Feedback Control Mechanisms Underlying Osmoregulation in Yeast -- 5 Analysis of Synchronizing Biochemical Networks via Incremental Dissipativity -- 6 Robustness Model Validation of Bistability in Biomolecular Systems -- 7 Meta-DNA: A DNA-Based Approach to Synthetic Biology -- 8 Towards Modeling Automation for Synthetic Biology -- 9 An Investigation of Signal Transduction and Irreversible Decision Making through Monostable and Bistable Switches -- 10 From Specification to Parameters: A Linearization Approach -- 11 Simplified Computational Design of Digital Synthetic Gene Circuits -- 12 Synthetic Biochemical Devices for Programmable Dynamic Behavior -- Index
Dimensions
unknown
Extent
XVIII, 298 p. 107 illus., 77 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9789401790475
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-94-017-9047-5
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-94-017-9047-5
Label
A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems, edited by Vishwesh V. Kulkarni, Guy-Bart Stan, Karthik Raman, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
1 Network Biomarker Construction for Molecular Investigation and Diagnosis of Lung Cancervia Microarray Data -- 2 The Impact of Next Generation Sequencing Technology on Bacterial Genomics -- 3 Sensitivity Analysis of Circadian Entrainment in the Space of Phase Response Curves -- 4 Modelling and Analysis of Feedback Control Mechanisms Underlying Osmoregulation in Yeast -- 5 Analysis of Synchronizing Biochemical Networks via Incremental Dissipativity -- 6 Robustness Model Validation of Bistability in Biomolecular Systems -- 7 Meta-DNA: A DNA-Based Approach to Synthetic Biology -- 8 Towards Modeling Automation for Synthetic Biology -- 9 An Investigation of Signal Transduction and Irreversible Decision Making through Monostable and Bistable Switches -- 10 From Specification to Parameters: A Linearization Approach -- 11 Simplified Computational Design of Digital Synthetic Gene Circuits -- 12 Synthetic Biochemical Devices for Programmable Dynamic Behavior -- Index
Dimensions
unknown
Extent
XVIII, 298 p. 107 illus., 77 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9789401790475
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-94-017-9047-5
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-94-017-9047-5

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