The Resource Alzheimer’s Disease : Advances in Genetics, Molecular and Cellular Biology, edited by Sangram S. Sisodia, Rudolph E. Tanzi, (electronic resource)

Alzheimer’s Disease : Advances in Genetics, Molecular and Cellular Biology, edited by Sangram S. Sisodia, Rudolph E. Tanzi, (electronic resource)

Label
Alzheimer’s Disease : Advances in Genetics, Molecular and Cellular Biology
Title
Alzheimer’s Disease
Title remainder
Advances in Genetics, Molecular and Cellular Biology
Statement of responsibility
edited by Sangram S. Sisodia, Rudolph E. Tanzi
Creator
Contributor
Editor
Provider
Subject
Language
eng
Summary
Alzheimer’s Disease: Advances in Genetics, Cellular and Molecular Biology provides exciting, comprehensive and up-to-date summaries of the most important recent advances in the genetic, molecular, biochemical, and cell biological studies of AD. The studies and advances described in this volume will help to accelerate the process of rational drug discovery and soon serve to extend and enhance the mental health and lifespan of our burgeoning elderly population. In 1906, Dr. Alois Alzheimer presented the case of his patient, Auguste D., a 51 year-old female admitted to the local asylum who presented with early memory impairments, psychoses, hallucinations and morbid jealousy. Dr. Alzheimer would argue that specific lesions that were present in and around neurons were responsible for dementia. In the ensuing decades, studies of the disorder that affected Auguste D., which would be named Alzheimer’s disease (AD), were largely limited to descriptive neuropathological and psychological assessments of this disease, but with little understanding of the molecular and cellular mechanisms underlying neurodegeneration and dementia. This would change in the 1980s when the protein components of the major neuropathological hallmarks of the disease, senile plaques (and cerebral blood vessel amyloid) and neurofibrillary tangles were first determined. The identification of the ß-amyloid protein (Aß) and the microtubule-associated tau protein as the main components of plaques and tangles, respectively, would pave the way for the molecular genetic era of AD research. By the late-1980s, the genes encoding the ß-amyloid precursor protein (APP) and tau (MAPT) were identified and would subsequently be shown to harbor autosomal dominant mutations causing early-onset familial AD and frontal temporal dementia (FTD), respectively. In the early 1990s, the e4 variant of the apoliprotein E gene (APOE) would be found to be associated with increased risk for late-onset AD. APP mutations increased the generation and subsequent deposition of the neurotoxic peptide, Aß42, in brain while APOE-e4 affected aggregation of Aß into fibrils and its clearance from brain. In 1995, genes encoding presenilin 1 and 2 (PSEN1, PSEN2) were identified, and mutations in MAPT were linked to frontal temporal dementia. Thus, by 1995, the stage was set for molecular studies of age-related dementias with APP, presenilin 1 and 2, APOE, and tau playing the major roles. The vast majority of studies addressing the molecular mechanisms underlying dementia would continue to focus on characterizing the five genes already firmly implicated in the etiology and pathogenesis of these dementing disorders, and these efforts have provided a firm foundation for translational studies that will hopefully serve to take these findings from the bench top to the bedside designing and developing novel ways to diagnose, treat, and prevent these diseases
Member of
http://library.link/vocab/creatorName
Sisodia, Sangram S
Image bit depth
0
LC call number
RC321-580
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
  • Tanzi, Rudolph E.
  • SpringerLink
http://library.link/vocab/subjectName
  • Medicine
  • Neurosciences
  • Toxicology
  • Geriatrics
  • Neurology
  • Neurobiology
  • Biomedicine
  • Neurosciences
  • Neurobiology
  • Neurology
  • Pharmacology/Toxicology
  • Geriatrics/Gerontology
  • Medicine/Public Health, general
Label
Alzheimer’s Disease : Advances in Genetics, Molecular and Cellular Biology, edited by Sangram S. Sisodia, Rudolph E. Tanzi, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
The Genetics of Alzheimer’s Disease -- APP Biology, Processing and Function -- The Biology of the Presenilin Complexes -- ?-secretase: Physiological Role and Target Validation -- Cognitive Impairment in Transgenic A? and Tau Models of Alzheimer’s Disease -- Cholesterol and ?-Amyloid -- A? Structure and Aggregation -- Signaling Mechanisms that Mediate A? Induced Neuronal Dysfunction -- Beta Amyloid and Excitatory Synapses -- A? Degradation -- Role of A ? Transport and Clearance in the Pathogenesis and Treatment of Alzheimer’s Disease -- Tau Gene Mutations in FTDP-17 Syndromes -- Animal Models of Tauopathy -- Tau and Axonal Transport -- Growth Factors in Alzheimer’s Disease
Dimensions
unknown
Extent
IX, 286 p.
File format
multiple file formats
Form of item
electronic
Isbn
9780387351353
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-0-387-35135-3
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-0-387-35135-3
Label
Alzheimer’s Disease : Advances in Genetics, Molecular and Cellular Biology, edited by Sangram S. Sisodia, Rudolph E. Tanzi, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
The Genetics of Alzheimer’s Disease -- APP Biology, Processing and Function -- The Biology of the Presenilin Complexes -- ?-secretase: Physiological Role and Target Validation -- Cognitive Impairment in Transgenic A? and Tau Models of Alzheimer’s Disease -- Cholesterol and ?-Amyloid -- A? Structure and Aggregation -- Signaling Mechanisms that Mediate A? Induced Neuronal Dysfunction -- Beta Amyloid and Excitatory Synapses -- A? Degradation -- Role of A ? Transport and Clearance in the Pathogenesis and Treatment of Alzheimer’s Disease -- Tau Gene Mutations in FTDP-17 Syndromes -- Animal Models of Tauopathy -- Tau and Axonal Transport -- Growth Factors in Alzheimer’s Disease
Dimensions
unknown
Extent
IX, 286 p.
File format
multiple file formats
Form of item
electronic
Isbn
9780387351353
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-0-387-35135-3
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-0-387-35135-3

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