The Resource Assessing equivalence and noninferiority, investigators, Jonathan Treadwell ... [et al.], (electronic resource)

Assessing equivalence and noninferiority, investigators, Jonathan Treadwell ... [et al.], (electronic resource)

Label
Assessing equivalence and noninferiority
Title
Assessing equivalence and noninferiority
Statement of responsibility
investigators, Jonathan Treadwell ... [et al.]
Contributor
Subject
Genre
Language
  • eng
  • eng
Summary
OBJECTIVE: To provide guidance on how to manage the concepts of equivalence and noninferiority in the context of systematic reviews. METHODS: This guidance was developed by a workgroup consisting of 13 individuals from seven Evidence-based Practice Centers (EPCs) and the Agency for Healthcare Research and Quality, under the leadership of the ECRI EPC. Prior to developing any guidance, the lead EPC also performed two methods projects intended to assist the workgroup. The first was a review of 12 existing guidance documents pertaining to equivalence and noninferiority, all of which were intended for primary researchers. The second project assessed the methodology used for a random sample of 50 recent systematic reviews that concluded equivalence or noninferiority between two or more treatments. Based on the previous experience and knowledge of the workgroup members, as well as insights from the two methods projects, guidance was developed and underwent posting for public comment and peer review. RESULTS: No guidance documents specifically addressing equivalence and noninferiority in the context of systematic review were identified. The workgroup developed a list of recommendations for four areas. First, how to assess the unique risk of bias for trials self-identifying as equivalence or noninferiority trials. Second, how to set Minimum Important Difference for a systematic review. Third, the analytic foundations for concluding equivalence or noninferiority in a systematic review. Fourth, language considerations when concluding equivalence or noninferiority in a systematic review. CONCLUSIONS: Systematic reviewers need to adopt a consistent and conceptually sound approach to interpreting, concluding, and expressing equivalence or noninferiority in the context of systematic reviews. This paper provides preliminary guidance in that endeavor
Member of
Cataloging source
DNLM
Funding information
Prepared for: Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services, 540 Gaither Road, Rockville, MD 20850; www.ahrq.gov Contract No. 290-2007-10063, Prepared by: EPC Workgroup: ECRI Institute Evidence-based Practice Center, Plymouth Meeting, PA; Johns Hopkins University Evidence-based Practice Center, Baltimore, MD; McMaster University Evidence-based Practice Center, Hamilton, Ontario, Canada; Oregon Evidence-based Practice Center, Portland, OR; Research Triangle Institute Evidence-based Practice Center, Research Triangle Park, NC; University of Connecticut Evidence-based Practice Center, Hartford, CT; University of Minnesota Evidence-based Practice Center, Minneapolis, MN; The University of Adelaide, Australia; Agency for Healthcare Research and Quality, Rockville, MD
Government publication
federal national government publication
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QV 771.4
http://library.link/vocab/relatedWorkOrContributorDate
1968-
http://library.link/vocab/relatedWorkOrContributorName
  • Treadwell, Jonathan R.
  • United States
  • EPC Workgroup
Series statement
  • Methods research report
  • AHRQ publication
Series volume
no. 12-EHC045-EF
http://library.link/vocab/subjectName
  • Clinical Trials as Topic
  • Review Literature as Topic
Label
Assessing equivalence and noninferiority, investigators, Jonathan Treadwell ... [et al.], (electronic resource)
Instantiates
Publication
Note
  • "June 2012."
  • "Contract No. 290-2007-10063."
Bibliography note
Includes bibliographical references
Color
multicolored
Dimensions
unknown
Extent
1 online resource (PDF file (various pagings)).
Form of item
online
Specific material designation
remote
System control number
  • 1592180
  • (DNLM)BKSHLF:NBK98979
Label
Assessing equivalence and noninferiority, investigators, Jonathan Treadwell ... [et al.], (electronic resource)
Publication
Note
  • "June 2012."
  • "Contract No. 290-2007-10063."
Bibliography note
Includes bibliographical references
Color
multicolored
Dimensions
unknown
Extent
1 online resource (PDF file (various pagings)).
Form of item
online
Specific material designation
remote
System control number
  • 1592180
  • (DNLM)BKSHLF:NBK98979

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