The Resource Biomolecular Interfaces : Interactions, Functions and Drug Design, by Ariel Fernández Stigliano, (electronic resource)

Biomolecular Interfaces : Interactions, Functions and Drug Design, by Ariel Fernández Stigliano, (electronic resource)

Label
Biomolecular Interfaces : Interactions, Functions and Drug Design
Title
Biomolecular Interfaces
Title remainder
Interactions, Functions and Drug Design
Statement of responsibility
by Ariel Fernández Stigliano
Creator
Contributor
Author
Provider
Subject
Language
eng
Summary
The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior. The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and biomolecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering
http://library.link/vocab/creatorName
Fernández Stigliano, Ariel
Image bit depth
0
LC call number
QD431-431.7
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
SpringerLink
http://library.link/vocab/subjectName
  • Life sciences
  • Medicine
  • Pharmaceutical technology
  • RNA-ligand interactions
  • Cell membranes
  • Life Sciences
  • Protein-Ligand Interactions
  • Membrane Biology
  • Molecular Medicine
  • Pharmaceutical Sciences/Technology
  • Biophysics and Biological Physics
Label
Biomolecular Interfaces : Interactions, Functions and Drug Design, by Ariel Fernández Stigliano, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
The Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology -- Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water -- Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistructural Approaches -- Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface -- Proteins in the Order-Disorder Twilight: Unstable Interfaces Promote Protein Aggregation -- Evolution of Protein Structure Degradation and Lessons for the Drug Designer -- Chemical Functionality of the Aqueous Interface in Soluble Proteins -- The Biomolecular Interface as a Selectivity Filter for Drug-Based Targeted Therapy -- Wrapping-Based Re-Engineering of an Anticancer Drug to Make it Safer -- Biomolecular Interfaces Provide Universal Markers for Drug Specificity and Personalized Medicine -- Controlling Induced Folding Through Wrapping Drug Design -- Wrapping Drug Combinations for Therapeutic Editing of Side Effects: Systems Biology Meets Wrapping Technology -- Multi-Target Control of Drug Impact: A Therapeutic Imperative in Cancer Systems Biology -- Engineering Therapeutic Alignments between Immune Response and Molecularly Targeted Cancer Treatment -- High-Level Quantum Chemistry Empowers the Wrapping Technology for Drug Design -- Epilogue -- Appendix 1. Code for Dehydron Identification -- Appendix 2. Solutions of Problems
Dimensions
unknown
Extent
XIX, 372 p. 145 illus., 86 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319168500
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-3-319-16850-0
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-16850-0
Label
Biomolecular Interfaces : Interactions, Functions and Drug Design, by Ariel Fernández Stigliano, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
The Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology -- Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water -- Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistructural Approaches -- Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface -- Proteins in the Order-Disorder Twilight: Unstable Interfaces Promote Protein Aggregation -- Evolution of Protein Structure Degradation and Lessons for the Drug Designer -- Chemical Functionality of the Aqueous Interface in Soluble Proteins -- The Biomolecular Interface as a Selectivity Filter for Drug-Based Targeted Therapy -- Wrapping-Based Re-Engineering of an Anticancer Drug to Make it Safer -- Biomolecular Interfaces Provide Universal Markers for Drug Specificity and Personalized Medicine -- Controlling Induced Folding Through Wrapping Drug Design -- Wrapping Drug Combinations for Therapeutic Editing of Side Effects: Systems Biology Meets Wrapping Technology -- Multi-Target Control of Drug Impact: A Therapeutic Imperative in Cancer Systems Biology -- Engineering Therapeutic Alignments between Immune Response and Molecularly Targeted Cancer Treatment -- High-Level Quantum Chemistry Empowers the Wrapping Technology for Drug Design -- Epilogue -- Appendix 1. Code for Dehydron Identification -- Appendix 2. Solutions of Problems
Dimensions
unknown
Extent
XIX, 372 p. 145 illus., 86 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319168500
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-3-319-16850-0
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-16850-0

Library Locations

  • African Studies LibraryBorrow it
    771 Commonwealth Avenue, 6th Floor, Boston, MA, 02215, US
    42.350723 -71.108227
  • Alumni Medical LibraryBorrow it
    72 East Concord Street, Boston, MA, 02118, US
    42.336388 -71.072393
  • Astronomy LibraryBorrow it
    725 Commonwealth Avenue, 6th Floor, Boston, MA, 02445, US
    42.350259 -71.105717
  • Fineman and Pappas Law LibrariesBorrow it
    765 Commonwealth Avenue, Boston, MA, 02215, US
    42.350979 -71.107023
  • Frederick S. Pardee Management LibraryBorrow it
    595 Commonwealth Avenue, Boston, MA, 02215, US
    42.349626 -71.099547
  • Howard Gotlieb Archival Research CenterBorrow it
    771 Commonwealth Avenue, 5th Floor, Boston, MA, 02215, US
    42.350723 -71.108227
  • Mugar Memorial LibraryBorrow it
    771 Commonwealth Avenue, Boston, MA, 02215, US
    42.350723 -71.108227
  • Music LibraryBorrow it
    771 Commonwealth Avenue, 2nd Floor, Boston, MA, 02215, US
    42.350723 -71.108227
  • Pikering Educational Resources LibraryBorrow it
    2 Silber Way, Boston, MA, 02215, US
    42.349804 -71.101425
  • School of Theology LibraryBorrow it
    745 Commonwealth Avenue, 2nd Floor, Boston, MA, 02215, US
    42.350494 -71.107235
  • Science & Engineering LibraryBorrow it
    38 Cummington Mall, Boston, MA, 02215, US
    42.348472 -71.102257
  • Stone Science LibraryBorrow it
    675 Commonwealth Avenue, Boston, MA, 02445, US
    42.350103 -71.103784
Processing Feedback ...