The Resource Comprehensive overview of methods and reporting of meta-analyses of test accuracy, investigators, Issa J Dahabreh ... [et al.], (electronic resource)

Comprehensive overview of methods and reporting of meta-analyses of test accuracy, investigators, Issa J Dahabreh ... [et al.], (electronic resource)

Label
Comprehensive overview of methods and reporting of meta-analyses of test accuracy
Title
Comprehensive overview of methods and reporting of meta-analyses of test accuracy
Statement of responsibility
investigators, Issa J Dahabreh ... [et al.]
Contributor
Subject
Language
  • eng
  • eng
Summary
BACKGROUND: Medical tests play a critical role in disease screening, diagnosis, and prediction of future outcomes. Meta-analyses of diagnostic or predictive test accuracy are increasingly performed and the relevant methods are continuously evolving. METHODS: We identified systematic reviews including quantitative synthesis (meta-analysis) of test accuracy for diagnostic or predictive medical tests through MEDLINE searches (1966 to December 2009) and perusal of reference lists of eligible articles and relevant reviews. We extracted information on topics and test types covered, methods for literature synthesis and quality assessment, availability of data, and statistical analyses performed. RESULTS: Our searches retrieved 1,225 potentially eligible reviews of which 760 (published from 1987 to 2009) were finally considered eligible for inclusion. Eligible reviews included a median of 18 primary studies and typically examined a single index test against a single reference standard. The number of publications increased per calendar year (P < 0.001). Most meta-analyses pertained to cardiovascular disease (21 percent) and oncology (25 percent); the most common test categories were imaging (44 percent) and biomarker tests (28 percent). Meta-analyses used multiple electronic databases (62 percent used at least one electronic database in addition to MEDLINE; P for trend over time < 0.001) to identify eligible studies. There was a striking increase in the proportion of systematic reviews that reported assessing verification bias (P for trend < 0.001), spectrum bias (P for trend = 0.007), blinding (P for trend < 0.001), prospective study design (P for trend < 0.001), or consecutive patient recruitment (P for trend < 0.001), over time. Improvements were associated with reporting of using quality-item checklists to guide assessment of methodological quality. In statistical analyses, sensitivity (in 77 percent), specificity (in 74 percent) and diagnostic/predictive odds ratios (in 34 percent) were the most commonly used metrics. Heterogeneity tests were used in 58 percent, and subgroup or regression analyses were used in 57 percent of meta-analyses. Random effects models were employed in 57 percent of the reviews and increasingly over time (P for trend < 0.001). Theoretically motivated methods that model sensitivity and specificity simultaneously, while accounting for between-study heterogeneity, were used in a minority of reviews (11 percent) but increasingly over time (P for trend < 0.001). CONCLUSION: Meta-analyses of diagnostic or predictive tests are increasingly performed. Over time there have been substantial improvements in the literature review, quality assessment and statistical analysis methods employed. Much of the improvement in quality assessment is associated with the use of quality item checklists. Advanced statistical methods have been increasingly adopted over time but their use still remains limited
Member of
Cataloging source
DNLM
Funding information
Prepared for: Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services, 540 Gaither Road, Rockville, MD 20850; www.ahrq.gov Contract No. 290-2007-10055-I. Prepared by: Tufts Evidence-based Practice Center, Boston, MA
Government publication
federal national government publication
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WB 141
http://library.link/vocab/relatedWorkOrContributorName
  • Dahabreh, Issa J
  • United States
  • Tufts Evidence-based Practice Center
Series statement
  • Methods research report
  • AHRQ publication
Series volume
no. 12-EHC044-EF
http://library.link/vocab/subjectName
  • Diagnostic Techniques and Procedures
  • Meta-Analysis as Topic
  • Reproducibility of Results
Label
Comprehensive overview of methods and reporting of meta-analyses of test accuracy, investigators, Issa J Dahabreh ... [et al.], (electronic resource)
Instantiates
Publication
Note
"March 2012."
Bibliography note
Includes bibliographical references
Color
black and white
Dimensions
unknown
Extent
1 online resource (PDF file (various pagings))
Form of item
online
Other physical details
ill.
Specific material designation
remote
System control number
  • 1583984
  • (DNLM)BKSHLF:NBK92422
Label
Comprehensive overview of methods and reporting of meta-analyses of test accuracy, investigators, Issa J Dahabreh ... [et al.], (electronic resource)
Publication
Note
"March 2012."
Bibliography note
Includes bibliographical references
Color
black and white
Dimensions
unknown
Extent
1 online resource (PDF file (various pagings))
Form of item
online
Other physical details
ill.
Specific material designation
remote
System control number
  • 1583984
  • (DNLM)BKSHLF:NBK92422

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