The Resource Development of antibody-based therapeutics : translational considerations, Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp, editors, (electronic resource)

Development of antibody-based therapeutics : translational considerations, Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp, editors, (electronic resource)

Label
Development of antibody-based therapeutics : translational considerations
Title
Development of antibody-based therapeutics
Title remainder
translational considerations
Statement of responsibility
Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp, editors
Contributor
Provider
Subject
Genre
Language
eng
Summary
Development of Antibody-Based Therapeutics: Translational Considerations examines important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics. Translational strategies for development of antibody-based therapeutics require an understanding of the relationship between the ‘unit dose’ and ‘unit effect’ with respect to both beneficial and deleterious biological effects from early stages of development. The flow of information across various stages of development should provide opportunities to facilitate selection of more effective novel and next-generation drug candidates. Successful strategies for the development of monoclonal antibodies require integration of knowledge with regards to target antigen properties in health and disease, as well as antibody design criteria including affinity, isotype selection, pharmacokinetics/pharmacodynamics (PK/PD) properties, antibody cross-reactivity across species, and safety. Selection and evaluation of appropriate biomarkers in early preclinical development in “relevant” animal models should allow identification of potential risks and liabilities of an antibody drug candidate to humans and establishment of safe First-In-Human (FIH) dosing strategies. This volume provides a comprehensive review of the topics critical for establishing successful translational strategies for the development of antibody-based therapeutics
Cataloging source
GW5XE
Image bit depth
0
LC call number
RM282.M65
LC item number
D48 2012
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
  • SpringerLink
  • Tabrizi, Mohammad A
  • Bornstein, Gadi G
  • Klakamp, Scott L
http://library.link/vocab/subjectName
  • Monoclonal antibodies
  • Pharmacology/Toxicology
  • Biochemistry, general
  • MEDICAL
  • Médecine
  • Monoclonal antibodies
Label
Development of antibody-based therapeutics : translational considerations, Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp, editors, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Translational Strategies for Development of Antibody-Based Therapeutics: An Overview -- Discovery Process for Antibody-Based Therapeutics -- Technologies for the Generation of Human Antibodies -- Application of Antibody Engineering in the Development of Next Generation Antibody-Based Therapeutics -- Biophysical Considerations -- Considerations in Establishing Affinity Design Goals -- BioAnalytical Considerations: Pharmacokinetics and Immunogenicity -- Antibody-Based Therapeutics in Oncology : Preclinical Considerations -- Factors Impacting the Tumor Localization and Distribution -- Antibody-Based Therapeutics: Preclinical Safety Considerations -- Application of Pharmacokinetic/Pharmacodynamic Modeling -- Design of Translational Strategies : Application of Population Pharmacokinetic-Pharmacodynamic (PK-PD) Approaches -- Translational Biomarkers: Essential Tools in Development of Antibody-Based Therapeutics -- Development of Antibody-Based Therapeutics: Translational Research in Alzheimer’s Disease -- Considerations in Manufacturing Process Development -- Next Generation Antibody-Based Therapeutics -- Immune Complex Therapies for Treatment of Immune Thrombocytopenia (ITP) -- Application of Bioinformatics Principles for Target Evaluation -- Concluding Remarks
Dimensions
unknown
Extent
1 online resource (xiv, 425 pages)
File format
multiple file formats
Form of item
  • online
  • electronic
Isbn
9781441959553
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-1-4419-5955-3
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (OCoLC)793100550
  • (OCoLC)ocn793100550
Label
Development of antibody-based therapeutics : translational considerations, Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp, editors, (electronic resource)
Publication
Antecedent source
mixed
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Translational Strategies for Development of Antibody-Based Therapeutics: An Overview -- Discovery Process for Antibody-Based Therapeutics -- Technologies for the Generation of Human Antibodies -- Application of Antibody Engineering in the Development of Next Generation Antibody-Based Therapeutics -- Biophysical Considerations -- Considerations in Establishing Affinity Design Goals -- BioAnalytical Considerations: Pharmacokinetics and Immunogenicity -- Antibody-Based Therapeutics in Oncology : Preclinical Considerations -- Factors Impacting the Tumor Localization and Distribution -- Antibody-Based Therapeutics: Preclinical Safety Considerations -- Application of Pharmacokinetic/Pharmacodynamic Modeling -- Design of Translational Strategies : Application of Population Pharmacokinetic-Pharmacodynamic (PK-PD) Approaches -- Translational Biomarkers: Essential Tools in Development of Antibody-Based Therapeutics -- Development of Antibody-Based Therapeutics: Translational Research in Alzheimer’s Disease -- Considerations in Manufacturing Process Development -- Next Generation Antibody-Based Therapeutics -- Immune Complex Therapies for Treatment of Immune Thrombocytopenia (ITP) -- Application of Bioinformatics Principles for Target Evaluation -- Concluding Remarks
Dimensions
unknown
Extent
1 online resource (xiv, 425 pages)
File format
multiple file formats
Form of item
  • online
  • electronic
Isbn
9781441959553
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-1-4419-5955-3
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (OCoLC)793100550
  • (OCoLC)ocn793100550

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