The Resource Drug class review : final report update 2, Newer antihistamines, prepared by Susan Carson, Nancy Lee, Sujata Thakurta, (electronic resource)

Drug class review : final report update 2, Newer antihistamines, prepared by Susan Carson, Nancy Lee, Sujata Thakurta, (electronic resource)

Label
Drug class review : final report update 2, Newer antihistamines
Title
Drug class review
Title remainder
final report update 2
Title part
Newer antihistamines
Statement of responsibility
prepared by Susan Carson, Nancy Lee, Sujata Thakurta
Title variation
Newer antihistamines
Creator
Contributor
Subject
Genre
Language
  • eng
  • eng
Summary
Antihistamines inhibit the effects of histamine at H1 receptors. They have a number of clinical indications including allergic conditions (e.g., rhinitis, dermatoses, atopic dermatitis, contact dermatitis, allergic conjunctivitis, hypersensitivity reactions to drugs, mild transfusion reactions, and urticaria), chronic idiopathic urticaria (CIU), motion sickness, vertigo, and insomnia. First-generation antihistamines are highly lipophilic and therefore readily cross the blood-brain barrier, contributing to adverse central nervous system effects, including sedation, drowsiness, and decreased cognitive processing. Newer antihistamines were developed to decrease the adverse effects of first generation drug. "Second generation" antihistamines have higher specificity for binding to H1 receptors, lower affinity for non-histamine receptors, and are lipo-phobic (thus have poor penetration of the blood brain barrier). Third generation antihistamines are natural metabolites of first generation drugs, developed with the goal of improving clinical efficacy and minimizing side-effects. The purpose of this review was to compare the efficacy, effectiveness, and adverse effects of newer antihistamines in both adult and pediatric populations
Member of
Cataloging source
DNLM
http://library.link/vocab/creatorName
Carson, Susan
Funding information
The Drug Effectiveness Review Project, composed of 12 organizations including 11 state Medicaid agencies and the Canadian Agency for Drugs and Technology in Health commissioned and funded for this report. These organizations selected the topic of the report and had input into its Key Questions. The content and conclusions of the report were entirely determined by the Evidence-based Practice Center researchers. The authors of this report have no financial interest in any company that makes or distributes the products reviewed in this report.
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • surveys of literature
NLM call number
QV 157
http://library.link/vocab/relatedWorkOrContributorName
  • Lee, Nancy J
  • Thakurta, Sujata
  • Drug Effectiveness Review Project
  • Oregon Health & Science University
  • Oregon Health & Science University
Series statement
Drug class reviews
http://library.link/vocab/subjectName
  • Histamine Antagonists
  • Histamine Antagonists
  • Treatment Outcome
  • Drug Toxicity
Label
Drug class review : final report update 2, Newer antihistamines, prepared by Susan Carson, Nancy Lee, Sujata Thakurta, (electronic resource)
Instantiates
Publication
Note
  • Title from PDF cover (viewed on July 26, 2011)
  • "May 2010."
Bibliography note
Includes bibliographical references
Dimensions
unknown
Extent
1 online resource.
Form of item
online
Specific material designation
remote
System control number
  • 1553881
  • (DNLM)BKSHLF:NBK50558
Label
Drug class review : final report update 2, Newer antihistamines, prepared by Susan Carson, Nancy Lee, Sujata Thakurta, (electronic resource)
Publication
Note
  • Title from PDF cover (viewed on July 26, 2011)
  • "May 2010."
Bibliography note
Includes bibliographical references
Dimensions
unknown
Extent
1 online resource.
Form of item
online
Specific material designation
remote
System control number
  • 1553881
  • (DNLM)BKSHLF:NBK50558

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