The Resource Drug class review : final update 5 report, Second-generation antidepressants, Gerald Gartlehner ... [et al.] ; produced by RTI-UNC Evidence-based Practice Center, Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, (electronic resource)

Drug class review : final update 5 report, Second-generation antidepressants, Gerald Gartlehner ... [et al.] ; produced by RTI-UNC Evidence-based Practice Center, Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, (electronic resource)

Label
Drug class review : final update 5 report, Second-generation antidepressants
Title
Drug class review
Title remainder
final update 5 report
Title part
Second-generation antidepressants
Statement of responsibility
Gerald Gartlehner ... [et al.] ; produced by RTI-UNC Evidence-based Practice Center, Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill
Title variation
Second-generation antidepressants
Contributor
Subject
Genre
Language
  • eng
  • eng
Summary
PURPOSE: We compared the effectiveness and harms of second-generation antidepressants in the treatment of major depressive disorder (MDD), dysthymia, subsyndromal depression, seasonal affective disorder, generalized anxiety disorder, obsessive compulsive disorder, panic disorder, post-traumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder. DATA SOURCES: We searched PubMed, Embase, PsycINFO, the Cochrane Library, and the International Pharmaceutical Abstracts until September 2010. For additional data we also hand searched reference lists, US Food and Drug Administration medical and statistical reviews and dossiers submitted by pharmaceutical companies. REVIEW METHODS: Study selection, data abstraction, validity assessment, grading the strength of the evidence, and data synthesis were all carried out according to standard Drug Effectiveness Review Project review methods. RESULTS AND CONCLUSIONS: Overall, we found no substantial differences in comparative efficacy and effectiveness of second-generation antidepressants for the treatment of depressive or anxiety disorders. Differences exist in the incidence of specific adverse events and the onset of action. Except for MDD, the evidence is limited to few direct comparisons for most indications. No head-to-head evidence is available for MDD in pediatric populations, dysthymia, subsyndromal depression, seasonal affective disorder, and premenstrual dysphoric disorder
Member of
Cataloging source
DNLM
Funding information
Funding: The Drug Effectiveness Review Project, composed of 12 organizations including 11 state Medicaid agencies, and the Canadian Agency for Drugs and Technology in Health commissioned and funded for this report. These organizations selected the topic of the report and had input into its Key Questions. The content and conclusions of the report were entirely determined by the Evidence-based Practice Center researchers. The authors of this report have no financial interest in any company that makes or distributes the products reviewed in this report.
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • surveys of literature
NLM call number
QV 77.5
http://library.link/vocab/relatedWorkOrContributorName
  • Gartlehner, Gerald
  • Research Triangle Institute-University of North Carolina Evidence-based Practice Center
  • Cecil G. Sheps Center for Health Services Research
  • Oregon Health & Science University
  • Oregon Health & Science University
  • Drug Effectiveness Review Project
Series statement
Drug class reviews
http://library.link/vocab/subjectName
  • Antidepressive Agents, Second-Generation
  • Antidepressive Agents, Second-Generation
  • Serotonin Uptake Inhibitors
  • Serotonin Uptake Inhibitors
Label
Drug class review : final update 5 report, Second-generation antidepressants, Gerald Gartlehner ... [et al.] ; produced by RTI-UNC Evidence-based Practice Center, Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, (electronic resource)
Instantiates
Publication
Note
  • "March 2011."
  • Title from PDF t.p. (viewed on Sept. 9, 2011)
Bibliography note
Includes bibliographical references
Dimensions
unknown
Extent
1 online resource (1 PDF file (190 p.)
Form of item
online
Other physical details
ill.).
Specific material designation
remote
System control number
  • 1563656
  • (DNLM)BKSHLF:NBK54355
Label
Drug class review : final update 5 report, Second-generation antidepressants, Gerald Gartlehner ... [et al.] ; produced by RTI-UNC Evidence-based Practice Center, Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, (electronic resource)
Publication
Note
  • "March 2011."
  • Title from PDF t.p. (viewed on Sept. 9, 2011)
Bibliography note
Includes bibliographical references
Dimensions
unknown
Extent
1 online resource (1 PDF file (190 p.)
Form of item
online
Other physical details
ill.).
Specific material designation
remote
System control number
  • 1563656
  • (DNLM)BKSHLF:NBK54355

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