The Resource Drug class review on fixed dose combination drug products for the treatment of type 2 diabetes and hyperlipidemia : final report, Marian McDonagh ... [et al.], (electronic resource)

Drug class review on fixed dose combination drug products for the treatment of type 2 diabetes and hyperlipidemia : final report, Marian McDonagh ... [et al.], (electronic resource)

Label
Drug class review on fixed dose combination drug products for the treatment of type 2 diabetes and hyperlipidemia : final report
Title
Drug class review on fixed dose combination drug products for the treatment of type 2 diabetes and hyperlipidemia
Title remainder
final report
Statement of responsibility
Marian McDonagh ... [et al.]
Contributor
Subject
Genre
Language
  • eng
  • eng
Summary
The combination of 2 drug entities in one dosage form is known as a fixed-dose combination product (FDCP). For the treatment of type 2 diabetes, there are 2 products that combine a sulfonylurea with metformin, 2 that combine metformin with a thiazolidinedione, 1 that combines metformin with a Dipeptidyl-Peptidase 4 (DPP-4) Inhibitor, and 2 that combine a thiazolidinedione with a sulfonylurea. For treatment of hyperlipidemia, 2 FDCPs are available: Vytorin and Advicor. Advicor is a combination of an HMG-CoA Reductase Inhibitor (statin) - lovastatin with an extended release formulation of niacin, while Vytorin is a combination of another statin, simvastatin, and a newer drug ezetimibe. Although the individual components of the FDCPs in this report have been shown to improve health outcomes, we believe it is still important to show whether outcomes are the same under the conditions of the FDCP where it is suggested that adherence and convenience are improved but dose adjustments are more difficult. The purpose of this review is to determine whether the purported advantages of taking 1 pill rather than 2 to treat hyperlipidemia and type 2 diabetes outweigh the potential disadvantages of not being able to adjust the doses of the two drugs separately
Member of
Cataloging source
DNLM
Funding information
The funding source, the Center for Evidence-based Policy, is supported by 17 organizations, including 15 state Medicaid programs. These organizations selected the topic and had input into the Key Questions for this review. The content and conclusions of the review are entirely determined by the Evidence-based Practice Center researchers. The authors of this report have no financial interest in any company that makes or distributes the products reviewed in this report.
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • reviews
NLM call number
WK 810
http://library.link/vocab/relatedWorkOrContributorName
  • McDonagh, Marian S
  • Oregon Health & Science University
Series statement
Drug class reviews
http://library.link/vocab/subjectName
  • Diabetes Mellitus, Type 2
  • Hyperlipidemias
  • Drug Therapy, Combination
  • Drug Evaluation
Label
Drug class review on fixed dose combination drug products for the treatment of type 2 diabetes and hyperlipidemia : final report, Marian McDonagh ... [et al.], (electronic resource)
Instantiates
Publication
Note
Title from PDF title page (viewed June 3, 2011)
Bibliography note
Includes bibliographical references
Color
black and white
Dimensions
unknown
Extent
1 online resource (PDF file (72 p.)).
Form of item
online
Specific material designation
remote
System control number
  • 1559725
  • (DNLM)BKSHLF:NBK10488
Label
Drug class review on fixed dose combination drug products for the treatment of type 2 diabetes and hyperlipidemia : final report, Marian McDonagh ... [et al.], (electronic resource)
Publication
Note
Title from PDF title page (viewed June 3, 2011)
Bibliography note
Includes bibliographical references
Color
black and white
Dimensions
unknown
Extent
1 online resource (PDF file (72 p.)).
Form of item
online
Specific material designation
remote
System control number
  • 1559725
  • (DNLM)BKSHLF:NBK10488

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