The Resource Endogenous Stem Cell-Based Brain Remodeling in Mammals, edited by Marie-Pierre Junier, Steven G. Kernie, (electronic resource)

Endogenous Stem Cell-Based Brain Remodeling in Mammals, edited by Marie-Pierre Junier, Steven G. Kernie, (electronic resource)

Label
Endogenous Stem Cell-Based Brain Remodeling in Mammals
Title
Endogenous Stem Cell-Based Brain Remodeling in Mammals
Statement of responsibility
edited by Marie-Pierre Junier, Steven G. Kernie
Creator
Contributor
Editor
Provider
Subject
Language
eng
Summary
This book uses the juvenile mammalian brain as a starting point to describe how different injury mechanisms influence neuronal and glial progenitor response to injury, and how in certain circumstances, these cells might play adaptive or harmful roles in recovery. It also provides an overview of emerging concepts in progenitor biology and how current understanding of the processes regulating these cells has tempered some of the initial enthusiasm regarding their therapeutic potential. Only recently has significant effort been devoted to the study of late neurogenesis in mammals, though this interesting phenomenon was first described over fifty years ago. In many settings, injury accelerates the ongoing neurogenesis now known to occur, and recently described reservoirs of glial progenitors add to the pool of existing reparative possibilities. Dr. Steven G. Kernie is an Associate Professor of Pediatrics and Pathology & Cell Biology at Columbia University in New York and Chief of Critical Care Medicine at Morgan Stanley Children’s Hospital at Columbia University Medical Center. His laboratory is interested in how the brain repairs itself following injury. The presence of adult neural stem and progenitor cells in the mammalian brain has awakened new interest and optimism in potential treatment for a variety of acquired brain disorders. The Kernie lab is investigating how adult neural stem and progenitor cells participate in injury-induced remodeling and in identifying genes and drugs that might be important in augmenting their contribution. In order to do this, they have generated a variety of transgenic mice that allow for temporally controlled alterations in the endogenous stem cell population in order to optimize the post-injury remodeling that occurs. Dr. Marie-Pierre Junier is Research Director at Inserm and co-PI of team Glial Plasticity for the Center of Research Neuroscience Paris Seine at the University Pierre et Marie Curie. Her team showed the permissiveness of astrocytes to re-programming into immature states akin to neural progenitors or neural stem cells. It further demonstrated that these plastic capabilities of astrocytes sensitize them to cancerous transformation. The team is now using cancer stem cells isolated from human adult and pediatric gliomas to understand their differences from normal human neural stem cells. Combining proteomic, metabolic and epigenetic approaches, the team aims at developing new therapeutic strategies against these devastating cancers
Member of
http://library.link/vocab/creatorName
Junier, Marie-Pierre
Image bit depth
0
LC call number
QH588.S83
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
  • Kernie, Steven G.
  • SpringerLink
Series statement
Stem Cell Biology and Regenerative Medicine,
http://library.link/vocab/subjectName
  • Life sciences
  • Oncology
  • Neurosciences
  • Neurochemistry
  • Cytology
  • Stem cells
  • Life Sciences
  • Stem Cells
  • Cell Biology
  • Neurosciences
  • Neurochemistry
  • Cancer Research
Label
Endogenous Stem Cell-Based Brain Remodeling in Mammals, edited by Marie-Pierre Junier, Steven G. Kernie, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction -- Structural Plasticity in Adult Nervous System: A Historic Perspective -- Impact of Injured Tissue on Stem Cell Fate -- Role of Neural Stem and Progenitor Cells in the Adaptation of the Brain to Injury -- Role of Adult Neurogenesis in Seizure-Induced Hippocampal Remodeling and Epilepsy -- Neurogenesis and Gliogenesis in the Postnatal Hypothalamus: a new level of plasticity for the regulation of hypothalamic function? -- Regenerative Potential of NG2 Cells -- Oligodendrocyte Progenitors and Brain Remodeling Following Blood Brain Barrier Rupture -- Genomic Integrity of Embryonic and Neural Stem Cells -- Links Between Injury-Induced Brain Remodeling and Oncogenesis?
Dimensions
unknown
Extent
VIII, 230 p. 21 illus., 19 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9781489973993
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-4899-7399-3
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-1-4899-7399-3
Label
Endogenous Stem Cell-Based Brain Remodeling in Mammals, edited by Marie-Pierre Junier, Steven G. Kernie, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction -- Structural Plasticity in Adult Nervous System: A Historic Perspective -- Impact of Injured Tissue on Stem Cell Fate -- Role of Neural Stem and Progenitor Cells in the Adaptation of the Brain to Injury -- Role of Adult Neurogenesis in Seizure-Induced Hippocampal Remodeling and Epilepsy -- Neurogenesis and Gliogenesis in the Postnatal Hypothalamus: a new level of plasticity for the regulation of hypothalamic function? -- Regenerative Potential of NG2 Cells -- Oligodendrocyte Progenitors and Brain Remodeling Following Blood Brain Barrier Rupture -- Genomic Integrity of Embryonic and Neural Stem Cells -- Links Between Injury-Induced Brain Remodeling and Oncogenesis?
Dimensions
unknown
Extent
VIII, 230 p. 21 illus., 19 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9781489973993
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-4899-7399-3
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-1-4899-7399-3

Library Locations

  • African Studies LibraryBorrow it
    771 Commonwealth Avenue, 6th Floor, Boston, MA, 02215, US
    42.350723 -71.108227
  • Alumni Medical LibraryBorrow it
    72 East Concord Street, Boston, MA, 02118, US
    42.336388 -71.072393
  • Astronomy LibraryBorrow it
    725 Commonwealth Avenue, 6th Floor, Boston, MA, 02445, US
    42.350259 -71.105717
  • Fineman and Pappas Law LibrariesBorrow it
    765 Commonwealth Avenue, Boston, MA, 02215, US
    42.350979 -71.107023
  • Frederick S. Pardee Management LibraryBorrow it
    595 Commonwealth Avenue, Boston, MA, 02215, US
    42.349626 -71.099547
  • Howard Gotlieb Archival Research CenterBorrow it
    771 Commonwealth Avenue, 5th Floor, Boston, MA, 02215, US
    42.350723 -71.108227
  • Mugar Memorial LibraryBorrow it
    771 Commonwealth Avenue, Boston, MA, 02215, US
    42.350723 -71.108227
  • Music LibraryBorrow it
    771 Commonwealth Avenue, 2nd Floor, Boston, MA, 02215, US
    42.350723 -71.108227
  • Pikering Educational Resources LibraryBorrow it
    2 Silber Way, Boston, MA, 02215, US
    42.349804 -71.101425
  • School of Theology LibraryBorrow it
    745 Commonwealth Avenue, 2nd Floor, Boston, MA, 02215, US
    42.350494 -71.107235
  • Science & Engineering LibraryBorrow it
    38 Cummington Mall, Boston, MA, 02215, US
    42.348472 -71.102257
  • Stone Science LibraryBorrow it
    675 Commonwealth Avenue, Boston, MA, 02445, US
    42.350103 -71.103784
Processing Feedback ...