Coverart for item
The Resource Evaluating Evidence of Mechanisms in Medicine : Principles and Procedures, by Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P Kelly, Charles Norell, Federica Russo, Beth Shaw, Jon Williamson, (electronic resource)

Evaluating Evidence of Mechanisms in Medicine : Principles and Procedures, by Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P Kelly, Charles Norell, Federica Russo, Beth Shaw, Jon Williamson, (electronic resource)

Label
Evaluating Evidence of Mechanisms in Medicine : Principles and Procedures
Title
Evaluating Evidence of Mechanisms in Medicine
Title remainder
Principles and Procedures
Statement of responsibility
by Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P Kelly, Charles Norell, Federica Russo, Beth Shaw, Jon Williamson
Creator
Contributor
Author
Provider
Subject
Language
eng
Summary
This book is open access under a CC BY license. This book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence of mechanisms, for evaluating evidence of mechanisms, and for combining this evaluation with evidence of association in order to yield an overall assessment of effectiveness. Evidence-based medicine seeks to achieve improved health outcomes by making evidence explicit and by developing explicit methods for evaluating it. To date, evidence-based medicine has largely focused on evidence of association produced by clinical studies. As such, it has tended to overlook evidence of pathophysiological mechanisms and evidence of the mechanisms of action of interventions. The book offers a useful guide for all those whose work involves evaluating evidence in the health sciences, including those who need to determine the effectiveness of health interventions and those who need to ascertain the effects of environmental exposures
Member of
http://library.link/vocab/creatorName
Parkkinen, Veli-Pekka
Image bit depth
0
LC call number
R723-723.7
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
  • Wallmann, Christian.
  • Wilde, Michael.
  • Clarke, Brendan.
  • Illari, Phyllis.
  • Kelly, Michael P.
  • Norell, Charles.
  • Russo, Federica.
  • Shaw, Beth.
  • Williamson, Jon.
  • SpringerLink
Series statement
SpringerBriefs in Philosophy,
http://library.link/vocab/subjectName
  • Philosophy
  • Knowledge, Theory of
  • Medicine
  • Philosophy
  • Philosophy of Medicine
  • Epistemology
Label
Evaluating Evidence of Mechanisms in Medicine : Principles and Procedures, by Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P Kelly, Charles Norell, Federica Russo, Beth Shaw, Jon Williamson, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
1 Introduction -- 1.1 What is a mechanism? -- 1.2 Where does evidence of a mechanism come from? -- 1.3 Why consider evidence of mechanisms? -- 1.3.1 Evaluating efficacy -- 1.3.2 Evaluating external validity -- 1.3.3 Other questions -- 1.3.4 Importance of considering evidence of mechanisms -- 2 How to consider evidence of mechanisms: a summary -- 2.1 Questions to address -- 2.2 Quality level of evidence and status of claim -- 2.3 Identifying evidence of mechanisms in the literature -- 2.4 Evaluating evidence of mechanisms -- 2.5 Using evidence of mechanisms to evaluate causal claims -- 2.6 Overall approach -- 3 Identifying evidence of mechanisms in the literature -- 3.1 Hypothesize a mechanism -- 3.2 Search the literature -- 3.3 Identify the evidence most relevant to the mechanism hypothesis -- 3.4 Presenting the evidence of mechanisms -- 4 Evaluating evidence of mechanisms -- 4.1 Considerations for evaluating evidence of mechanism -- 4.2 Presenting quality of evidence of mechanisms -- 5 Using evidence of mechanisms to evaluate efficacy and external validity -- 5.1 Efficacy -- 5.2 External validity -- 6 Glossary -- 7 References -- 8 Acknowledgements -- 9 Appendix A. A critical appraisal tool for evidence of mechanisms -- 10 Appendix B. GRADE tables with mechanism assessment -- 11 Appendix C: Databases for evidence of mechanisms -- 12 Appendix D: Assessing exposures -- 12.1 Example: carcinogenicity of benzo[a]pyrene -- 12.2 Comparison to IARC -- 12.3 Molecular epidemiology -- 12.4 Comparison to SYRINA
Dimensions
unknown
Extent
XVIII, 125 p. 14 illus.
File format
multiple file formats
Form of item
electronic
Governing access note
Open Access
Isbn
9783319946108
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-3-319-94610-8
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-94610-8
Label
Evaluating Evidence of Mechanisms in Medicine : Principles and Procedures, by Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P Kelly, Charles Norell, Federica Russo, Beth Shaw, Jon Williamson, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
1 Introduction -- 1.1 What is a mechanism? -- 1.2 Where does evidence of a mechanism come from? -- 1.3 Why consider evidence of mechanisms? -- 1.3.1 Evaluating efficacy -- 1.3.2 Evaluating external validity -- 1.3.3 Other questions -- 1.3.4 Importance of considering evidence of mechanisms -- 2 How to consider evidence of mechanisms: a summary -- 2.1 Questions to address -- 2.2 Quality level of evidence and status of claim -- 2.3 Identifying evidence of mechanisms in the literature -- 2.4 Evaluating evidence of mechanisms -- 2.5 Using evidence of mechanisms to evaluate causal claims -- 2.6 Overall approach -- 3 Identifying evidence of mechanisms in the literature -- 3.1 Hypothesize a mechanism -- 3.2 Search the literature -- 3.3 Identify the evidence most relevant to the mechanism hypothesis -- 3.4 Presenting the evidence of mechanisms -- 4 Evaluating evidence of mechanisms -- 4.1 Considerations for evaluating evidence of mechanism -- 4.2 Presenting quality of evidence of mechanisms -- 5 Using evidence of mechanisms to evaluate efficacy and external validity -- 5.1 Efficacy -- 5.2 External validity -- 6 Glossary -- 7 References -- 8 Acknowledgements -- 9 Appendix A. A critical appraisal tool for evidence of mechanisms -- 10 Appendix B. GRADE tables with mechanism assessment -- 11 Appendix C: Databases for evidence of mechanisms -- 12 Appendix D: Assessing exposures -- 12.1 Example: carcinogenicity of benzo[a]pyrene -- 12.2 Comparison to IARC -- 12.3 Molecular epidemiology -- 12.4 Comparison to SYRINA
Dimensions
unknown
Extent
XVIII, 125 p. 14 illus.
File format
multiple file formats
Form of item
electronic
Governing access note
Open Access
Isbn
9783319946108
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-3-319-94610-8
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-94610-8

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