The Resource Fluorescent Tools for Imaging Oxidative Stress in Biology, by Amandeep Kaur, (electronic resource)

Fluorescent Tools for Imaging Oxidative Stress in Biology, by Amandeep Kaur, (electronic resource)

Label
Fluorescent Tools for Imaging Oxidative Stress in Biology
Title
Fluorescent Tools for Imaging Oxidative Stress in Biology
Statement of responsibility
by Amandeep Kaur
Creator
Contributor
Author
Provider
Subject
Language
eng
Summary
This thesis advances the long-standing challenge of measuring oxidative stress and deciphering its underlying mechanisms, and also outlines the advantages and limitations of existing design strategies. It presents a range of approaches for the chemical synthesis of fluorescent probes that detect reversible changes in cellular oxidative stress. The ability to visualise cellular processes in real-time is crucial to understanding disease development and streamline treatment, and this can be achieved using fluorescent tools that can sense reversible disturbances in cellular environments during pathogenesis. The perturbations in cellular redox state are of particular current interest in medical research, since oxidative stress is implicated in the pathogenesis of a number of diseases. The book investigates different strategies used to achieve ratiometric fluorescence output of the reversible redox probes, which nullify concentration effects associated with intensity-based probes. It also describes suitable approaches to target these probes to specific cellular organelles, thereby enabling medical researchers to visualise sub-cellular oxidative stress levels, and addressing the typically poor uptake of chemical tools into biological studies. In total it reports on four new probes that are now being used by over twenty research groups around the globe, and two of which have been commercialised. The final chapters of this thesis demonstrate successful applications of the sensors in a variety of biological systems ranging from prokaryotes to mammalian cells and whole organisms. The results described clearly indicate the immense value of collaborative, cross-disciplinary research
Member of
http://library.link/vocab/creatorName
Amandeep Kaur
Image bit depth
0
LC call number
QD71-142
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
SpringerLink
Series statement
Springer Theses, Recognizing Outstanding Ph.D. Research,
http://library.link/vocab/subjectName
  • Chemistry
  • Biomedical engineering
  • Chemistry, Analytic
  • Chemistry, Physical and theoretical
  • Oxidative stress
  • Chemistry
  • Analytical Chemistry
  • Oxidative Stress
  • Biological and Medical Physics, Biophysics
  • Biomedical Engineering/Biotechnology
  • Physical Chemistry
Label
Fluorescent Tools for Imaging Oxidative Stress in Biology, by Amandeep Kaur, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction -- Flavin based redox probes -- FRET based ratiometric redox probes -- Mitochondrially-targeted ratiometric redox probes -- Nicotinamide based ratiometric probes -- In cellulo studies -- Ex vivo studies -- Non-mammalian systems -- Conclusions -- Experimental Methods.
Dimensions
unknown
Extent
XLV, 230 p.
File format
multiple file formats
Form of item
electronic
Isbn
9783319734057
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-319-73405-7
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-73405-7
Label
Fluorescent Tools for Imaging Oxidative Stress in Biology, by Amandeep Kaur, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction -- Flavin based redox probes -- FRET based ratiometric redox probes -- Mitochondrially-targeted ratiometric redox probes -- Nicotinamide based ratiometric probes -- In cellulo studies -- Ex vivo studies -- Non-mammalian systems -- Conclusions -- Experimental Methods.
Dimensions
unknown
Extent
XLV, 230 p.
File format
multiple file formats
Form of item
electronic
Isbn
9783319734057
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-319-73405-7
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-73405-7

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