The Resource Formation and cooperative behaviour of protein complexes on the cell membrane, Ksenia Guseva, (electronic resource)

Formation and cooperative behaviour of protein complexes on the cell membrane, Ksenia Guseva, (electronic resource)

Label
Formation and cooperative behaviour of protein complexes on the cell membrane
Title
Formation and cooperative behaviour of protein complexes on the cell membrane
Statement of responsibility
Ksenia Guseva
Creator
Contributor
Provider
Subject
Language
eng
Summary
With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process
Member of
Cataloging source
GW5XE
http://library.link/vocab/creatorName
Guseva, Ksenia
Image bit depth
0
LC call number
QP552.M44
LC item number
G87 2012
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
SpringerLink
Series statement
Springer Theses
http://library.link/vocab/subjectName
  • Membrane proteins
  • Cell membranes
  • Physique
  • Astronomie
  • Cell membranes
  • Membrane proteins
Label
Formation and cooperative behaviour of protein complexes on the cell membrane, Ksenia Guseva, (electronic resource)
Instantiates
Publication
Note
Originally presented as the author's thesis (Ph. D)--University of Aberdeen
Antecedent source
mixed
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Introduction -- The Role of Fragmentation on the Formation of Homomeric Protein Complexes -- Collective Response of Self-organised Clusters of Mechanosensitive Channels -- Assembly and Fragmentation of Tat Pores -- Conclusion
Dimensions
unknown
Extent
1 online resource (xii, 80 pages)
File format
multiple file formats
Form of item
  • online
  • electronic
Isbn
9783642239885
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
9786613451835
Other physical details
illustrations (some color).
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
Stock number
345183
System control number
  • (OCoLC)756510633
  • (OCoLC)ocn756510633
Label
Formation and cooperative behaviour of protein complexes on the cell membrane, Ksenia Guseva, (electronic resource)
Publication
Note
Originally presented as the author's thesis (Ph. D)--University of Aberdeen
Antecedent source
mixed
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Introduction -- The Role of Fragmentation on the Formation of Homomeric Protein Complexes -- Collective Response of Self-organised Clusters of Mechanosensitive Channels -- Assembly and Fragmentation of Tat Pores -- Conclusion
Dimensions
unknown
Extent
1 online resource (xii, 80 pages)
File format
multiple file formats
Form of item
  • online
  • electronic
Isbn
9783642239885
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
9786613451835
Other physical details
illustrations (some color).
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
Stock number
345183
System control number
  • (OCoLC)756510633
  • (OCoLC)ocn756510633

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