The Resource Fundamentals of Neurodegeneration and Protein Misfolding Disorders, by Martin Beckerman, (electronic resource)

Fundamentals of Neurodegeneration and Protein Misfolding Disorders, by Martin Beckerman, (electronic resource)

Label
Fundamentals of Neurodegeneration and Protein Misfolding Disorders
Title
Fundamentals of Neurodegeneration and Protein Misfolding Disorders
Statement of responsibility
by Martin Beckerman
Creator
Contributor
Author
Provider
Subject
Language
eng
Summary
This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer’s disease and Parkinson’s disease to Huntington’s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today’s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering
Member of
http://library.link/vocab/creatorName
Beckerman, Martin
Image bit depth
0
LC call number
RC321-580
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
SpringerLink
Series statement
Biological and Medical Physics, Biomedical Engineering,
http://library.link/vocab/subjectName
  • Medicine
  • Neurosciences
  • Medicinal chemistry
  • Neurology
  • Proteins
  • Biophysics
  • Biological physics
  • Biomedical engineering
  • Biomedicine
  • Neurosciences
  • Biophysics and Biological Physics
  • Protein Science
  • Biomedical Engineering
  • Neurology
  • Medicinal Chemistry
Label
Fundamentals of Neurodegeneration and Protein Misfolding Disorders, by Martin Beckerman, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Introduction -- Protein Folding, Part I: Basic Principles -- Protein Folding, Part II: Energy Landscapes and Protein Dynamics -- Protein Misfolding and Aggregation -- Protein Quality Control, Part I: Molecular Chaperones and the Ubiquitin-Proteasome System -- Protein Quality Control, Part II: Autophagy and Aging -- Prion Diseases -- Alzheimer’s Disease -- Parkinson’s Disease -- Huntington’s Disease and other Unstable Repeat Disorders -- Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration
Dimensions
unknown
Edition
1st ed. 2015.
Extent
XXII, 378 p. 122 illus., 103 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319221175
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-3-319-22117-5
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-22117-5
Label
Fundamentals of Neurodegeneration and Protein Misfolding Disorders, by Martin Beckerman, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Introduction -- Protein Folding, Part I: Basic Principles -- Protein Folding, Part II: Energy Landscapes and Protein Dynamics -- Protein Misfolding and Aggregation -- Protein Quality Control, Part I: Molecular Chaperones and the Ubiquitin-Proteasome System -- Protein Quality Control, Part II: Autophagy and Aging -- Prion Diseases -- Alzheimer’s Disease -- Parkinson’s Disease -- Huntington’s Disease and other Unstable Repeat Disorders -- Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration
Dimensions
unknown
Edition
1st ed. 2015.
Extent
XXII, 378 p. 122 illus., 103 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319221175
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-3-319-22117-5
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-22117-5

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