The Resource Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins, by Raphael Enoque Ferraz de Paiva, (electronic resource)

Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins, by Raphael Enoque Ferraz de Paiva, (electronic resource)

Label
Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
Title
Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
Statement of responsibility
by Raphael Enoque Ferraz de Paiva
Creator
Contributor
Author
Author
Provider
Subject
Language
eng
Summary
This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling
Member of
http://library.link/vocab/creatorName
Ferraz de Paiva, Raphael Enoque
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsaut
wqq-D5Jcyuk
Image bit depth
0
LC call number
QD410-412.5
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
SpringerLink
Series statement
Springer Theses, Recognizing Outstanding Ph.D. Research,
http://library.link/vocab/subjectName
  • Chemistry, Organic
  • RNA-ligand interactions
  • Mass spectrometry
  • Bioorganic chemistry
  • Immunology
  • Biochemistry
  • Organometallic Chemistry
  • Protein-Ligand Interactions
  • Mass Spectrometry
  • Bioorganic Chemistry
  • Immunology
  • Medicinal Chemistry
Label
Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins, by Raphael Enoque Ferraz de Paiva, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Au(I)-phosphine series design -- Probing the Protein: Ion Mobility Spectrometry -- Probing Gold: X-ray Absorption Spectroscopy -- Probing Cells: Cytotoxicity Evaluation -- Au(III) series with k2C,N and k2N,N' ligands -- "Dual Probe" X-ray Absorption Spectroscopy
Dimensions
unknown
Extent
XXXIX, 151 p. 100 illus., 38 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783030008536
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-3-030-00853-6
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-030-00853-6
Label
Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins, by Raphael Enoque Ferraz de Paiva, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Au(I)-phosphine series design -- Probing the Protein: Ion Mobility Spectrometry -- Probing Gold: X-ray Absorption Spectroscopy -- Probing Cells: Cytotoxicity Evaluation -- Au(III) series with k2C,N and k2N,N' ligands -- "Dual Probe" X-ray Absorption Spectroscopy
Dimensions
unknown
Extent
XXXIX, 151 p. 100 illus., 38 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783030008536
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-3-030-00853-6
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-030-00853-6

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