The Resource HCV: The Journey from Discovery to a Cure : Volume I, edited by Michael J. Sofia, (electronic resource)

HCV: The Journey from Discovery to a Cure : Volume I, edited by Michael J. Sofia, (electronic resource)

Label
HCV: The Journey from Discovery to a Cure : Volume I
Title
HCV: The Journey from Discovery to a Cure
Title remainder
Volume I
Statement of responsibility
edited by Michael J. Sofia
Contributor
Editor
Editor
Subject
Language
eng
Summary
Hepatitis C is a liver disease caused by the hepatitis C virus (HCV) and infects approximately 75 million individuals worldwide. It is also one of the major causes of liver cancer and liver transplants. The elucidation of the HCV genome, and the development of a whole cell system to study the virus spurred the search for novel direct acting antiviral drugs to cure this disease. This global effort culminated in the development of direct acting antiviral drugs that led to cure rates approaching 100% in all patient populations after only 8-12 weeks of therapy. These efforts resulted in one of the greatest achievements in public health and provides the potential for eliminating HCV as a major disease worldwide. This volume is aimed at a broad audience of academic and industrial scientists interested in the discovery and development of drugs to treat viral diseases and those interested in reading about one of the most unique accomplishments in biomedical research. The volume will provide a one of a kind reference work that highlights the many efforts, from the discovery of the HCV virus, to the invention of breakthrough medicines and their use in the real world to cure patients. It is the companion book to the volume "HCV: The Journey from Discovery to a Cure - Volume II"
Member of
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
Tafj9PwDItg
Image bit depth
0
LC call number
RS400-431
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
Sofia, Michael J.
Series statement
Topics in Medicinal Chemistry,
Series volume
31
http://library.link/vocab/subjectName
  • Pharmaceutical chemistry
  • Virology
  • Clinical biochemistry
  • Bioorganic chemistry
  • Pharmaceutical technology
  • Medicinal Chemistry
  • Virology
  • Medical Biochemistry
  • Bioorganic Chemistry
  • Pharmaceutical Sciences/Technology
Label
HCV: The Journey from Discovery to a Cure : Volume I, edited by Michael J. Sofia, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Identification of the virus, the medical need and clearing the blood supply -- Mapping the HCV genome -- The molecular virology of HCV -- The development of the HCV replicon system -- The Evolution of IFN therapy for HCV -- Evolution of HCV NS5B Non-Nucleoside Inhibitors -- Evolution of HCV NS5B Nucleoside & Nucleotide Inhibitors -- Discovery and Development of Sofosbuvir -- Discovery of Beclabuvir -- Discovery of Dasabuvir -- Evolution of HCV NS3/4 protease inhibitors -- Discovery and Development of Telaprevir -- Discovery and Development of Boceprevir -- Discovery and Development of Asunaprevir.-Discovery and Development of Grazoprevir -- Discovery and Development of Simeprevir -- Discovery and Development of Paritaprevir & Glecaprevir
Dimensions
unknown
Edition
1st ed. 2019.
Extent
VIII, 463 p. 1 illus.
File format
multiple file formats
Form of item
electronic
Isbn
9783030282073
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-030-28207-3
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-030-28207-3
Label
HCV: The Journey from Discovery to a Cure : Volume I, edited by Michael J. Sofia, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Identification of the virus, the medical need and clearing the blood supply -- Mapping the HCV genome -- The molecular virology of HCV -- The development of the HCV replicon system -- The Evolution of IFN therapy for HCV -- Evolution of HCV NS5B Non-Nucleoside Inhibitors -- Evolution of HCV NS5B Nucleoside & Nucleotide Inhibitors -- Discovery and Development of Sofosbuvir -- Discovery of Beclabuvir -- Discovery of Dasabuvir -- Evolution of HCV NS3/4 protease inhibitors -- Discovery and Development of Telaprevir -- Discovery and Development of Boceprevir -- Discovery and Development of Asunaprevir.-Discovery and Development of Grazoprevir -- Discovery and Development of Simeprevir -- Discovery and Development of Paritaprevir & Glecaprevir
Dimensions
unknown
Edition
1st ed. 2019.
Extent
VIII, 463 p. 1 illus.
File format
multiple file formats
Form of item
electronic
Isbn
9783030282073
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-030-28207-3
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-030-28207-3

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