The Resource Human brain proteome, edited by Lisa A. Neuhold, (electronic resource)

Human brain proteome, edited by Lisa A. Neuhold, (electronic resource)

Label
Human brain proteome
Title
Human brain proteome
Statement of responsibility
edited by Lisa A. Neuhold
Contributor
Subject
Genre
Language
  • eng
  • eng
Summary
Proteomics is a systematic approach for studying the identity and function of all proteins expressed in a cell, tissue or organ. New drug targets for diseases are often identified by comparing the proteome of the disease state to the normal state. As a result, proteomics has become increasingly important in the pharmaceutical and biotechnology industries as well as academics. This book contains five sections encompassing the research aspects of proteomics on the brain including the most recent advances in the technology and informatics. It discusses advances in high-throughput proteomic tech
Member of
Is Subseries of
Cataloging source
MiAaPQ
Dewey number
  • 612.822
  • 612.822 22
Illustrations
illustrations
Index
index present
Language note
English
LC call number
RC343
LC item number
.H86 2004
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Neuhold, Lisa A
Series statement
International review of neurobiology
Series volume
v. 61
http://library.link/vocab/subjectName
  • Brain
  • Biochemical markers
  • Brain chemistry
  • Proteomics
Label
Human brain proteome, edited by Lisa A. Neuhold, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
  • Cover; Title Page; Copyright Page; Contents; Contents of Recent Volumes; Contributors; SECTION I: HIGH-THROUGHPUT TECHNOLOGIES; Chapter 1. Biomarker Discovery Using Molecular Profiling Approaches; I. Introduction; II. Transcriptomics; III. Proteomics Methodologies for Biomarker Discovery; IV. Principles of SELDI-TOF-MS; V. SELDI-TOF-MS in Clinical Proteomics Research; VI. Biomarkers in Specific Diseases; VII. Metabolomics; VIII. Conclusions; References; Chapter 2. Proteomic Analysis of Mitochondrial Proteins; I. Introduction; II. Model Systems; III. Technological Approaches
  • IV. Differential Expression of Proteins in Mouse Brain Mitochondria from Cortex and Synaptosomes.V. Conclusions; References; SECTION II: PROTEOMIC APPLICATIONS; Chapter 3. NMDA Receptors, Neural Pathways, and Protein Interaction Databases; I. Introduction; II. NMDA Receptor; III. Molecular Clustering; IV. Signal Transduction Pathways; VI. Proteomic Databases; VII. Future Directions; References; Chapter 4. Dopamine Transporter Network and Pathways; I. Introduction; II. Structure and Function of DAT; III. Cellular Localization of DAT; IV. Regulation of DAT; V. Mass Spectrometry-Based Proteomics
  • VI. Isolation and Validation of the DAT ProtomeVII. Mass Spectrometry; VIII. Confirmation of Members of the DAT Proteome; IX. In Silico Analysis of DAT Proteome; References; Chapter 5. Proteomic Approaches in Drug Discovery and Development; I. Proteomics in Drug Discovery and Development; II. Using Proteomics to Identify Biomarkers of Alzheimer's Disease: A Case Study; III. Future Challenges and Conclusions; References; SECTION III: INFORMATICS; Chapter 6. Proteomic Informatics; I. What is Proteomics?; II. Proteomic Informatics; III. Mass Spectrometry and Shotgun Proteomics
  • IV. Identifying ProteinsV. Post-hoc Validation of Protein Identification Program Output; VI. Quantification; VII. Detection of Protein Isoforms; VIII. Systems and Workflow Issues; IX. Conclusion; X. Appendix: List of Mentioned Algorithms by Topic; References; SECTION IV: CHANGES IN THE PROTEOME BY DISEASE; Chapter 7. Proteomics Analysis in Alzheimer's Disease: New Insights into Mechanisms of Neurodegeneration; I. Introduction; II. Proteomics Tools; III. Proteomic Studies in AD; IV. Proteomics Analysis of Transgenic Models of AD; V. Future of Proteomics in AD; References
  • Chapter 8. Proteomics and AlcoholismI. Introduction; II. Proteomics of the Hippocampus and Nucleus Accumbens; III. Future Directions; IV. Conclusion; References; Chapter 9. Proteomics Studies of Traumatic Brain Injury; I. Introduction; II. Traumatic Brain Injury; III. Proteomics Analysis Overview; IV. Protein Separation Methods; V. Protein Identification and Quantification Methods; VI. TBI Proteomics Bioinformatics; VII. Prospective Utilities of TBI Proteomics Data; References; Chapter 10. Influence of Huntington's Disease on the Human and Mouse Proteome; I. Introduction
  • II. Neurodegenerative Disorders Caused by Elongated Poly-Glutamine Repeats
Dimensions
unknown
Extent
1 online resource (351 p.)
Form of item
online
Isbn
9786611020422
Media category
computer
Media type code
  • c
Specific material designation
remote
System control number
  • (EBL)298269
  • (OCoLC)179704022
  • (SSID)ssj0000174772
  • (PQKBManifestationID)12065303
  • (PQKBTitleCode)TC0000174772
  • (PQKBWorkID)10188391
  • (PQKB)10598590
  • (MiAaPQ)EBC298269
  • (EXLCZ)991000000000364199
Label
Human brain proteome, edited by Lisa A. Neuhold, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
  • Cover; Title Page; Copyright Page; Contents; Contents of Recent Volumes; Contributors; SECTION I: HIGH-THROUGHPUT TECHNOLOGIES; Chapter 1. Biomarker Discovery Using Molecular Profiling Approaches; I. Introduction; II. Transcriptomics; III. Proteomics Methodologies for Biomarker Discovery; IV. Principles of SELDI-TOF-MS; V. SELDI-TOF-MS in Clinical Proteomics Research; VI. Biomarkers in Specific Diseases; VII. Metabolomics; VIII. Conclusions; References; Chapter 2. Proteomic Analysis of Mitochondrial Proteins; I. Introduction; II. Model Systems; III. Technological Approaches
  • IV. Differential Expression of Proteins in Mouse Brain Mitochondria from Cortex and Synaptosomes.V. Conclusions; References; SECTION II: PROTEOMIC APPLICATIONS; Chapter 3. NMDA Receptors, Neural Pathways, and Protein Interaction Databases; I. Introduction; II. NMDA Receptor; III. Molecular Clustering; IV. Signal Transduction Pathways; VI. Proteomic Databases; VII. Future Directions; References; Chapter 4. Dopamine Transporter Network and Pathways; I. Introduction; II. Structure and Function of DAT; III. Cellular Localization of DAT; IV. Regulation of DAT; V. Mass Spectrometry-Based Proteomics
  • VI. Isolation and Validation of the DAT ProtomeVII. Mass Spectrometry; VIII. Confirmation of Members of the DAT Proteome; IX. In Silico Analysis of DAT Proteome; References; Chapter 5. Proteomic Approaches in Drug Discovery and Development; I. Proteomics in Drug Discovery and Development; II. Using Proteomics to Identify Biomarkers of Alzheimer's Disease: A Case Study; III. Future Challenges and Conclusions; References; SECTION III: INFORMATICS; Chapter 6. Proteomic Informatics; I. What is Proteomics?; II. Proteomic Informatics; III. Mass Spectrometry and Shotgun Proteomics
  • IV. Identifying ProteinsV. Post-hoc Validation of Protein Identification Program Output; VI. Quantification; VII. Detection of Protein Isoforms; VIII. Systems and Workflow Issues; IX. Conclusion; X. Appendix: List of Mentioned Algorithms by Topic; References; SECTION IV: CHANGES IN THE PROTEOME BY DISEASE; Chapter 7. Proteomics Analysis in Alzheimer's Disease: New Insights into Mechanisms of Neurodegeneration; I. Introduction; II. Proteomics Tools; III. Proteomic Studies in AD; IV. Proteomics Analysis of Transgenic Models of AD; V. Future of Proteomics in AD; References
  • Chapter 8. Proteomics and AlcoholismI. Introduction; II. Proteomics of the Hippocampus and Nucleus Accumbens; III. Future Directions; IV. Conclusion; References; Chapter 9. Proteomics Studies of Traumatic Brain Injury; I. Introduction; II. Traumatic Brain Injury; III. Proteomics Analysis Overview; IV. Protein Separation Methods; V. Protein Identification and Quantification Methods; VI. TBI Proteomics Bioinformatics; VII. Prospective Utilities of TBI Proteomics Data; References; Chapter 10. Influence of Huntington's Disease on the Human and Mouse Proteome; I. Introduction
  • II. Neurodegenerative Disorders Caused by Elongated Poly-Glutamine Repeats
Dimensions
unknown
Extent
1 online resource (351 p.)
Form of item
online
Isbn
9786611020422
Media category
computer
Media type code
  • c
Specific material designation
remote
System control number
  • (EBL)298269
  • (OCoLC)179704022
  • (SSID)ssj0000174772
  • (PQKBManifestationID)12065303
  • (PQKBTitleCode)TC0000174772
  • (PQKBWorkID)10188391
  • (PQKB)10598590
  • (MiAaPQ)EBC298269
  • (EXLCZ)991000000000364199

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