The Resource LC-MS in drug bioanalysis, Q. Alan Xu, Timothy L. Madden, editors, (electronic resource)

LC-MS in drug bioanalysis, Q. Alan Xu, Timothy L. Madden, editors, (electronic resource)

Label
LC-MS in drug bioanalysis
Title
LC-MS in drug bioanalysis
Statement of responsibility
Q. Alan Xu, Timothy L. Madden, editors
Contributor
Provider
Subject
Language
eng
Summary
High performance liquid chromatography – mass spectrometry (LC-MS) combines the separation power of liquid chromatography with the high sensitivity and selectivity of mass spectrometry. Therefore, LC-MS becomes the method of choice for drug bioanalysis in therapeutic drug monitoring, toxicology, and drug discovery and development. LC-MS in Drug Bioanalysis offers discussions on: ● LC-MS/MS method development and validation in a regulated environment ● Internal standard use in LC-MS/MS bioanalysis ● Pitfalls of LC-MS/MS and how to overcome them ● Dried blood spot sampling ● Microflow LC-MS/MS ● LC-MS/MS in therapeutic drug monitoring ● Applications of LC-MS/MS in drug bioanalysis This book will aid readers to improve their skills in LC-MS/MS method development, validation, and applications in the analysis of drugs and their metabolites in complex biological matrices. In addition, this book provides detailed information on the bioanalysis of antidepressants, antipsychotics, steroid hormones, anticancer agents, and drugs of abuse. Newer methodologies are discussed including the use of unique sample preparation techniques and the implementation of imaging mass spectrometry in the localization of drug and drug metabolites in tissues
Cataloging source
GW5XE
Image bit depth
0
LC call number
RS189
LC item number
.L36 2012
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorDate
1961-
http://library.link/vocab/relatedWorkOrContributorName
  • SpringerLink
  • Xu, Quanyun A.
  • Madden, Timothy L
http://library.link/vocab/subjectName
  • Drugs
  • Liquid chromatography
  • Mass spectrometry
  • MEDICAL / Drug Guides
  • MEDICAL / Nursing / Pharmacology
  • MEDICAL / Pharmacology
  • MEDICAL / Pharmacy
  • Drugs
  • Liquid chromatography
  • Mass spectrometry
  • Science des matériaux
  • Chimie
Label
LC-MS in drug bioanalysis, Q. Alan Xu, Timothy L. Madden, editors, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Bibliography note
Includes bibliographical references and index
Color
not applicable
Contents
Internal standards for quantitative LC-MS bioanalysis -- Method development, validation and sample analysis for regulated quantitative bioanalysis using LC-MS/MS -- Impact of sampling paper/cards on bioanalytical quantitation via dried blood spots by liquid chromatography - mass spectrometry -- Highly sensitive pharmaceutical and clinical analysis using selective solid-phase extraction coupled to microflow liquid chromatography and isotope-dilution mass spectrometry -- Pitfalls of LC-MS/MS in the clinical laboratory -- Therapeutic drug monitoring to support clinical pharmacogenomics -- Liquid chromatography - mass spectrometry for the determination of antidepressants and some of their major metabolites in human biological matrices -- The analysis of antipsychotic drugs in human biosamples by LC-MS -- Therapeutic drug monitoring of targeted anticancer therapy - tyrosine kinase inhibitors and selective oestrogen receptor modulators: a clinical pharmacology laboratory perspective -- Applications of mass spectrometry in analyses of steroid hormones -- Liquid chromatography - mass spectrometric analysis of tropane alkaloids in mammalian samples: techniques and applications -- Analysis of illicit drugs in human biological samples by LC-MSn -- Use of matrix assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) in the development of novel small molecule drugs -- A planar integrated micro mass spectrometer
Dimensions
unknown
Extent
1 online resource.
File format
multiple file formats
Form of item
  • online
  • electronic
Isbn
9781461438281
Level of compression
uncompressed
Other control number
10.1007/978-1-4614-3828-1
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (OCoLC)800728408
  • (OCoLC)ocn800728408
Label
LC-MS in drug bioanalysis, Q. Alan Xu, Timothy L. Madden, editors, (electronic resource)
Publication
Antecedent source
mixed
Bibliography note
Includes bibliographical references and index
Color
not applicable
Contents
Internal standards for quantitative LC-MS bioanalysis -- Method development, validation and sample analysis for regulated quantitative bioanalysis using LC-MS/MS -- Impact of sampling paper/cards on bioanalytical quantitation via dried blood spots by liquid chromatography - mass spectrometry -- Highly sensitive pharmaceutical and clinical analysis using selective solid-phase extraction coupled to microflow liquid chromatography and isotope-dilution mass spectrometry -- Pitfalls of LC-MS/MS in the clinical laboratory -- Therapeutic drug monitoring to support clinical pharmacogenomics -- Liquid chromatography - mass spectrometry for the determination of antidepressants and some of their major metabolites in human biological matrices -- The analysis of antipsychotic drugs in human biosamples by LC-MS -- Therapeutic drug monitoring of targeted anticancer therapy - tyrosine kinase inhibitors and selective oestrogen receptor modulators: a clinical pharmacology laboratory perspective -- Applications of mass spectrometry in analyses of steroid hormones -- Liquid chromatography - mass spectrometric analysis of tropane alkaloids in mammalian samples: techniques and applications -- Analysis of illicit drugs in human biological samples by LC-MSn -- Use of matrix assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) in the development of novel small molecule drugs -- A planar integrated micro mass spectrometer
Dimensions
unknown
Extent
1 online resource.
File format
multiple file formats
Form of item
  • online
  • electronic
Isbn
9781461438281
Level of compression
uncompressed
Other control number
10.1007/978-1-4614-3828-1
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (OCoLC)800728408
  • (OCoLC)ocn800728408

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