The Resource Leptin : Regulation and Clinical Applications, edited by Sam Dagogo-Jack, MD, (electronic resource)

Leptin : Regulation and Clinical Applications, edited by Sam Dagogo-Jack, MD, (electronic resource)

Label
Leptin : Regulation and Clinical Applications
Title
Leptin
Title remainder
Regulation and Clinical Applications
Statement of responsibility
edited by Sam Dagogo-Jack, MD
Contributor
Editor
Provider
Subject
Language
eng
Summary
Twenty years after its discovery, recombinant human leptin has been approved by the Food and Drug Administration for the treatment of patients with lipodystrophy. Beginning with a synthesis of the vast body of work on its discovery, dissection of mechanisms, and effects in experimental models , the focus of this book shifts to a consideration of the regulation and role of leptin in humans. The emphasis on human-level data is a unique feature of this book. The results of numerous studies indicate that leptin is indeed a regulated human hormone. Leptin provides a detailed account of the myriad physiological, hormonal, metabolic, immunological, mitogenic and inflammatory modulators and targets of leptin in a single volume. Next follows a comprehensive presentation of the therapeutic trials of recombinant leptin in patients with congenital leptin deficiency, lipodystrophy, hypothalamic amenorrhea, and other emerging areas, including leptin supplementation in leptin-replete subjects, leptin substitution for insulin in diabetic models, and novel combination regimens of leptin and other biogenic peptides. Unanswered questions and future directions in leptin research are highlighted in the Foreword by Dr. Jeffrey Friedman and throughout the volume. Identifying such questions helps direct research that could deepen understanding of the complex regulation of leptin under physiological and pathological conditions, a critical prerequisite to its rational deployment in the treatment of human disorders
Image bit depth
0
LC call number
RC648-665.2
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
  • Dagogo-Jack, MD, Sam.
  • SpringerLink
http://library.link/vocab/subjectName
  • Medicine
  • Endocrinology
  • Metabolic diseases
  • Medicine & Public Health
  • Endocrinology
  • Metabolic Diseases
Label
Leptin : Regulation and Clinical Applications, edited by Sam Dagogo-Jack, MD, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Discovery of leptin and elucidation of leptin gene expression -- Leptin receptors and mechanism of action -- Leptin interaction with brain orexigenic and anorexigenic pathways -- Measurement of circulating leptin and soluble leptin receptors -- Physiological and hormonal factors that influence leptin production -- Leptin, obesity and leptin resistance -- Leptin and intermediary metabolism: Focus on glucoregulation and lipid metabolism -- Leptin in acute stress -- Leptin and the kidney -- Leptin, immune function, and inflammation -- Leptin and bone -- Leptin, cell cycle, and cancer -- Leptin, the autonomic nervous system, and hypertension -- Dynamic leptin secretion in obesity and diabetes -- Leptin therapy of congenital leptin deficiency -- Leptin therapy in people with normal leptin gene -- Leptin therapy in patients with lipodystrophy and syndromic insulin resistance -- Leptin therapy in women with hypothalamic amenorrhea -- Leptin therapy as a substitute for insulin replacement in experimental models of diabetes: Clinical implications in humans -- Novel combinatorial therapies involving leptin: Opportunities for mechanistic advances and therapeutic translation in human diseases
Dimensions
unknown
Extent
XXIII, 287 p. 48 illus., 27 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319099156
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-319-09915-6
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-09915-6
Label
Leptin : Regulation and Clinical Applications, edited by Sam Dagogo-Jack, MD, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Discovery of leptin and elucidation of leptin gene expression -- Leptin receptors and mechanism of action -- Leptin interaction with brain orexigenic and anorexigenic pathways -- Measurement of circulating leptin and soluble leptin receptors -- Physiological and hormonal factors that influence leptin production -- Leptin, obesity and leptin resistance -- Leptin and intermediary metabolism: Focus on glucoregulation and lipid metabolism -- Leptin in acute stress -- Leptin and the kidney -- Leptin, immune function, and inflammation -- Leptin and bone -- Leptin, cell cycle, and cancer -- Leptin, the autonomic nervous system, and hypertension -- Dynamic leptin secretion in obesity and diabetes -- Leptin therapy of congenital leptin deficiency -- Leptin therapy in people with normal leptin gene -- Leptin therapy in patients with lipodystrophy and syndromic insulin resistance -- Leptin therapy in women with hypothalamic amenorrhea -- Leptin therapy as a substitute for insulin replacement in experimental models of diabetes: Clinical implications in humans -- Novel combinatorial therapies involving leptin: Opportunities for mechanistic advances and therapeutic translation in human diseases
Dimensions
unknown
Extent
XXIII, 287 p. 48 illus., 27 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319099156
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-319-09915-6
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-09915-6

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