The Resource Microarrays for an integrative genomics, Isaac S. Kohane, Alvin T. Kho, and Atul J. Butte

Microarrays for an integrative genomics, Isaac S. Kohane, Alvin T. Kho, and Atul J. Butte

Label
Microarrays for an integrative genomics
Title
Microarrays for an integrative genomics
Statement of responsibility
Isaac S. Kohane, Alvin T. Kho, and Atul J. Butte
Creator
Contributor
Subject
Language
eng
Member of
Cataloging source
DLC
http://library.link/vocab/creatorName
Kohane, Isaac S
Illustrations
illustrations
Index
index present
LC call number
QP624.5.D726
LC item number
K686 2003
Literary form
non fiction
Nature of contents
bibliography
NLM call number
  • 2002 N-381
  • QZ 52
NLM item number
K79m 2003
http://library.link/vocab/relatedWorkOrContributorName
  • Kho, Alvin T
  • Butte, Atul J
http://library.link/vocab/subjectName
  • DNA microarrays
  • Genomics
  • Bioinformatics
  • Oligonucleotide Array Sequence Analysis
  • Computational Biology
  • Gene Expression Profiling
  • Genomics
  • Puces à ADN
  • Génomique
  • Bio-informatique
  • Data Mining
  • Genanalyse
  • Microarray
Label
Microarrays for an integrative genomics, Isaac S. Kohane, Alvin T. Kho, and Atul J. Butte
Instantiates
Publication
Note
"A Bradford book."
Bibliography note
Includes bibliographical references (p. [283]-295) and index
Carrier category
volume
Carrier category code
  • nc
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Basic Biology
  • Biological caveats in mRNA measurements
  • Sequence-level genomics
  • Proteomics
  • Experimental Design
  • The Safe Conception of a Functional Genomic Experiment
  • Experiment design space
  • Expression space
  • Exercising the expression space
  • Discarding data and low-hanging fruit
  • The Future Is So Bright ...
  • Gene-Clustering Dogma
  • Supervised versus unsupervised learning
  • Figure of merit: The elusive gold standard in functional genomics
  • Microarray Measurements to Analyses
  • Generic Features of Microarray Technologies
  • Robotically spotted microarrays
  • Oligonucleotide microarrays
  • Replicate Experiments, Reproducibility, and Noise
  • What is a replicate experiment? A reproducible experimental outcome?
  • Reproducibility across repeated microarray experiments: Absolute expression level and fold difference
  • Functional Genomics
  • Cross-platform (technology) reproducibility
  • Pooling sample probes and PCR for replicate experiments
  • What is noise?
  • Sources and examples of noise in the generic microarray experiment
  • Biological variation as noise: The Human Genome Project and irreproducibility of expression measurements
  • Managing noise
  • Prototypical Objectives and Questions
  • Two examples: Inter-array and intra-array
  • Informatics and advances in enabling technology
  • Why do we need new techniques?
  • Missing the Forest for the Dendrograms
  • Sociology of a functional genomics pipeline
  • Functional Genomics, Not Genetics
  • In silico analysis will never substitute for in vitro and in vivo
Dimensions
24 cm.
Extent
xviii, 306 pages
Isbn
9780262612104
Isbn Type
(pbk.)
Lccn
2002022663
Media category
unmediated
Media MARC source
rdamedia
Media type code
  • n
Other physical details
illustrations
System control number
  • (OCoLC)49305644
  • (OCoLC)ocm49305644
Label
Microarrays for an integrative genomics, Isaac S. Kohane, Alvin T. Kho, and Atul J. Butte
Publication
Note
"A Bradford book."
Bibliography note
Includes bibliographical references (p. [283]-295) and index
Carrier category
volume
Carrier category code
  • nc
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Basic Biology
  • Biological caveats in mRNA measurements
  • Sequence-level genomics
  • Proteomics
  • Experimental Design
  • The Safe Conception of a Functional Genomic Experiment
  • Experiment design space
  • Expression space
  • Exercising the expression space
  • Discarding data and low-hanging fruit
  • The Future Is So Bright ...
  • Gene-Clustering Dogma
  • Supervised versus unsupervised learning
  • Figure of merit: The elusive gold standard in functional genomics
  • Microarray Measurements to Analyses
  • Generic Features of Microarray Technologies
  • Robotically spotted microarrays
  • Oligonucleotide microarrays
  • Replicate Experiments, Reproducibility, and Noise
  • What is a replicate experiment? A reproducible experimental outcome?
  • Reproducibility across repeated microarray experiments: Absolute expression level and fold difference
  • Functional Genomics
  • Cross-platform (technology) reproducibility
  • Pooling sample probes and PCR for replicate experiments
  • What is noise?
  • Sources and examples of noise in the generic microarray experiment
  • Biological variation as noise: The Human Genome Project and irreproducibility of expression measurements
  • Managing noise
  • Prototypical Objectives and Questions
  • Two examples: Inter-array and intra-array
  • Informatics and advances in enabling technology
  • Why do we need new techniques?
  • Missing the Forest for the Dendrograms
  • Sociology of a functional genomics pipeline
  • Functional Genomics, Not Genetics
  • In silico analysis will never substitute for in vitro and in vivo
Dimensions
24 cm.
Extent
xviii, 306 pages
Isbn
9780262612104
Isbn Type
(pbk.)
Lccn
2002022663
Media category
unmediated
Media MARC source
rdamedia
Media type code
  • n
Other physical details
illustrations
System control number
  • (OCoLC)49305644
  • (OCoLC)ocm49305644

Library Locations

  • African Studies LibraryBorrow it
    771 Commonwealth Avenue, 6th Floor, Boston, MA, 02215, US
    42.350723 -71.108227
  • Alumni Medical LibraryBorrow it
    72 East Concord Street, Boston, MA, 02118, US
    42.336388 -71.072393
  • Astronomy LibraryBorrow it
    725 Commonwealth Avenue, 6th Floor, Boston, MA, 02445, US
    42.350259 -71.105717
  • Fineman and Pappas Law LibrariesBorrow it
    765 Commonwealth Avenue, Boston, MA, 02215, US
    42.350979 -71.107023
  • Frederick S. Pardee Management LibraryBorrow it
    595 Commonwealth Avenue, Boston, MA, 02215, US
    42.349626 -71.099547
  • Howard Gotlieb Archival Research CenterBorrow it
    771 Commonwealth Avenue, 5th Floor, Boston, MA, 02215, US
    42.350723 -71.108227
  • Mugar Memorial LibraryBorrow it
    771 Commonwealth Avenue, Boston, MA, 02215, US
    42.350723 -71.108227
  • Music LibraryBorrow it
    771 Commonwealth Avenue, 2nd Floor, Boston, MA, 02215, US
    42.350723 -71.108227
  • Pikering Educational Resources LibraryBorrow it
    2 Silber Way, Boston, MA, 02215, US
    42.349804 -71.101425
  • School of Theology LibraryBorrow it
    745 Commonwealth Avenue, 2nd Floor, Boston, MA, 02215, US
    42.350494 -71.107235
  • Science & Engineering LibraryBorrow it
    38 Cummington Mall, Boston, MA, 02215, US
    42.348472 -71.102257
  • Stone Science LibraryBorrow it
    675 Commonwealth Avenue, Boston, MA, 02445, US
    42.350103 -71.103784
Processing Feedback ...