The Resource Mitochondrial Biology and Experimental Therapeutics, edited by Paulo J. Oliveira, (electronic resource)

Mitochondrial Biology and Experimental Therapeutics, edited by Paulo J. Oliveira, (electronic resource)

Label
Mitochondrial Biology and Experimental Therapeutics
Title
Mitochondrial Biology and Experimental Therapeutics
Statement of responsibility
edited by Paulo J. Oliveira
Contributor
Editor
Provider
Subject
Language
eng
Summary
This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications
Image bit depth
0
LC call number
RM1-950
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
  • Oliveira, Paulo J.
  • SpringerLink
http://library.link/vocab/subjectName
  • Medicine
  • Pharmacology
  • Pharmaceutical chemistry
  • Clinical biochemistry
  • Oxidative stress
  • Biomedicine
  • Pharmacology/Toxicology
  • Medicinal Chemistry
  • Medical Biochemistry
  • Oxidative Stress
Label
Mitochondrial Biology and Experimental Therapeutics, edited by Paulo J. Oliveira, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Target Mitochondria -- SECTION I-Mitochondrial Biology -- Introduction: Mitochondria: the cell furnace -- MItochondria: Where are They Coming From? -- Mitochondrial Dynamics: A journey from Mitochondrial Morphology to MItochondrial Function and Quality -- Mitochondrial ROS, Oxidative Stress.and Aging- The Mitochondrial Permeability Transition Pore -- Mitochondrial Regulation of Cell Death -- MItochondria in Liver Diseases -- Mitochondria in Liver Regeneration,Energy Metabolism, and Posthepatectomy Liver Dysfunction -- MItochondrial Remodeling in Cancer -- Mitochondria in Kidney Disease -- CNS diseases and disruption of Mitochondria -- Mitochondrial disruption in cardiovascular diseases -- .Drug-inducing Mitochondrial Toxicity -- MItochondrial DNA: Functions and Role in Acquired Diseases -- SECTION II-MItochondrial Therapeutics: From the Bench to Industry and Patient -- The Evolution of Mitochondrial Toxicity Assessment in Industry -- Designing Mitochondrial-Active Molecules: The Road to MitoQ and Beyond -- Recovering Mitochondrial Function in Patients' Fibroblasts -- Targeting Mitochondria with Sweat: Improving Mitochondrial Function with Physical Activity -- Modulation of Cell Fate by Tauroursodexycholic Acid: All Paths Lead to Mitochondria -- Pharmacological Targeting of the Mitchondrial Permeability Transition Pore -- Strategies to Preserve/Improve Mitochondrial Function in Organ Preservation Solutions -- MItochondrial Targeted Redox Active Compounds and the Astrocytemotoneuron Axis: relevance for the Treatment of Amyotrophic Lateral Sclerosis -- Targeting the Mitochondrial Genome Through a Nanocarrier and the Regulation of the Mitochondrial Gene Experssion -- Mitochoncrial Dysfunction and Chronic Disease: Treatment with Membrane Lipid Replacement and other Natural Supplements -- Development of Mitochondrial-Directed Plastoquinones -- Targeted Mitochondrial Genome Editing -- Targeting Therpeutic Nucleic Acids into Mitochondria: A Long Challenge -- Cell Permeable Peptides Targeting Mitochondria -- MItochondrial -Directed Cancer Therapy -- SkQ1: The Road from the Bench to the Market -- MItochondrial Follies: Comic
Dimensions
unknown
Extent
IX, 708 p. 127 illus., 106 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319733449
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-319-73344-9
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-73344-9
Label
Mitochondrial Biology and Experimental Therapeutics, edited by Paulo J. Oliveira, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Target Mitochondria -- SECTION I-Mitochondrial Biology -- Introduction: Mitochondria: the cell furnace -- MItochondria: Where are They Coming From? -- Mitochondrial Dynamics: A journey from Mitochondrial Morphology to MItochondrial Function and Quality -- Mitochondrial ROS, Oxidative Stress.and Aging- The Mitochondrial Permeability Transition Pore -- Mitochondrial Regulation of Cell Death -- MItochondria in Liver Diseases -- Mitochondria in Liver Regeneration,Energy Metabolism, and Posthepatectomy Liver Dysfunction -- MItochondrial Remodeling in Cancer -- Mitochondria in Kidney Disease -- CNS diseases and disruption of Mitochondria -- Mitochondrial disruption in cardiovascular diseases -- .Drug-inducing Mitochondrial Toxicity -- MItochondrial DNA: Functions and Role in Acquired Diseases -- SECTION II-MItochondrial Therapeutics: From the Bench to Industry and Patient -- The Evolution of Mitochondrial Toxicity Assessment in Industry -- Designing Mitochondrial-Active Molecules: The Road to MitoQ and Beyond -- Recovering Mitochondrial Function in Patients' Fibroblasts -- Targeting Mitochondria with Sweat: Improving Mitochondrial Function with Physical Activity -- Modulation of Cell Fate by Tauroursodexycholic Acid: All Paths Lead to Mitochondria -- Pharmacological Targeting of the Mitchondrial Permeability Transition Pore -- Strategies to Preserve/Improve Mitochondrial Function in Organ Preservation Solutions -- MItochondrial Targeted Redox Active Compounds and the Astrocytemotoneuron Axis: relevance for the Treatment of Amyotrophic Lateral Sclerosis -- Targeting the Mitochondrial Genome Through a Nanocarrier and the Regulation of the Mitochondrial Gene Experssion -- Mitochoncrial Dysfunction and Chronic Disease: Treatment with Membrane Lipid Replacement and other Natural Supplements -- Development of Mitochondrial-Directed Plastoquinones -- Targeted Mitochondrial Genome Editing -- Targeting Therpeutic Nucleic Acids into Mitochondria: A Long Challenge -- Cell Permeable Peptides Targeting Mitochondria -- MItochondrial -Directed Cancer Therapy -- SkQ1: The Road from the Bench to the Market -- MItochondrial Follies: Comic
Dimensions
unknown
Extent
IX, 708 p. 127 illus., 106 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319733449
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-319-73344-9
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-73344-9

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