The Resource Modeling dose-response microarray data in early drug development experiments using R : order-restricted analysis of mircoarray data, Dan Lin... [et al.], editors, (electronic resource)

Modeling dose-response microarray data in early drug development experiments using R : order-restricted analysis of mircoarray data, Dan Lin... [et al.], editors, (electronic resource)

Label
Modeling dose-response microarray data in early drug development experiments using R : order-restricted analysis of mircoarray data
Title
Modeling dose-response microarray data in early drug development experiments using R
Title remainder
order-restricted analysis of mircoarray data
Statement of responsibility
Dan Lin... [et al.], editors
Contributor
Provider
Subject
Language
eng
Summary
This book focuses on the analysis of dose-response microarray data in pharmaceutical setting, the goal being to cover this important topic for early drug development and to provide user-friendly R packages that can be used to analyze dose-response microarray data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students. Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as the likelihood ratio test and non-linear parametric models, which are used in the second part of the book. Part II is the core of the book. Methodological topics discussed include: · Multiplicity adjustment · Test statistics and testing procedures for the analysis of dose-response microarray data · Resampling-based inference and use of the SAM method at the presence of small-variance genes in the data · Identification and classification of dose-response curve shapes · Clustering of order restricted (but not necessarily monotone) dose-response profiles · Hierarchical Bayesian models and non-linear models for dose-response microarray data · Multiple contrast tests All methodological issues in the book are illustrated using four “real-world” examples of dose-response microarray datasets from early drug development experiments
Member of
Cataloging source
GW5XE
Image bit depth
0
LC call number
RM301.8
LC item number
.M63 2012
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
  • SpringerLink
  • Lin, Dan
Series statement
Use R!
http://library.link/vocab/subjectName
  • Pharmaceutical Preparations
  • Dose-Response Relationship, Drug
  • Microarray Analysis
  • Drugs
  • Drugs
  • DNA microarrays
  • MEDICAL / Drug Guides
  • MEDICAL / Nursing / Pharmacology
  • MEDICAL / Pharmacology
  • MEDICAL / Pharmacy
Label
Modeling dose-response microarray data in early drug development experiments using R : order-restricted analysis of mircoarray data, Dan Lin... [et al.], editors, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Color
not applicable
Contents
Introduction -- Part I: Dose-response Modeling: An Introduction -- Estimation Under Order Restrictions -- The Likelihood Ratio Test -- Part II: Dose-response Microarray Experiments -- Functional Genomic Dose-response Experiments -- Adjustment for Multiplicity -- Test for Trend -- Order Restricted Bisclusters -- Classification of Trends in Dose-response Microarray Experiments Using Information Theory Selection Methods -- Multiple Contrast Test -- Confidence Intervals for the Selected Parameters -- Case Study Using GUI in R: Gene Expression Analysis After Acute Treatment With Antipsychotics
Dimensions
unknown
Extent
1 online resource.
File format
multiple file formats
Form of item
  • online
  • electronic
Isbn
9783642240072
Level of compression
uncompressed
Other control number
10.1007/978-3-642-24007-2
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (OCoLC)808682770
  • (OCoLC)ocn808682770
Label
Modeling dose-response microarray data in early drug development experiments using R : order-restricted analysis of mircoarray data, Dan Lin... [et al.], editors, (electronic resource)
Publication
Antecedent source
mixed
Color
not applicable
Contents
Introduction -- Part I: Dose-response Modeling: An Introduction -- Estimation Under Order Restrictions -- The Likelihood Ratio Test -- Part II: Dose-response Microarray Experiments -- Functional Genomic Dose-response Experiments -- Adjustment for Multiplicity -- Test for Trend -- Order Restricted Bisclusters -- Classification of Trends in Dose-response Microarray Experiments Using Information Theory Selection Methods -- Multiple Contrast Test -- Confidence Intervals for the Selected Parameters -- Case Study Using GUI in R: Gene Expression Analysis After Acute Treatment With Antipsychotics
Dimensions
unknown
Extent
1 online resource.
File format
multiple file formats
Form of item
  • online
  • electronic
Isbn
9783642240072
Level of compression
uncompressed
Other control number
10.1007/978-3-642-24007-2
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (OCoLC)808682770
  • (OCoLC)ocn808682770

Library Locations

  • African Studies LibraryBorrow it
    771 Commonwealth Avenue, 6th Floor, Boston, MA, 02215, US
    42.350723 -71.108227
  • Alumni Medical LibraryBorrow it
    72 East Concord Street, Boston, MA, 02118, US
    42.336388 -71.072393
  • Astronomy LibraryBorrow it
    725 Commonwealth Avenue, 6th Floor, Boston, MA, 02445, US
    42.350259 -71.105717
  • Fineman and Pappas Law LibrariesBorrow it
    765 Commonwealth Avenue, Boston, MA, 02215, US
    42.350979 -71.107023
  • Frederick S. Pardee Management LibraryBorrow it
    595 Commonwealth Avenue, Boston, MA, 02215, US
    42.349626 -71.099547
  • Howard Gotlieb Archival Research CenterBorrow it
    771 Commonwealth Avenue, 5th Floor, Boston, MA, 02215, US
    42.350723 -71.108227
  • Mugar Memorial LibraryBorrow it
    771 Commonwealth Avenue, Boston, MA, 02215, US
    42.350723 -71.108227
  • Music LibraryBorrow it
    771 Commonwealth Avenue, 2nd Floor, Boston, MA, 02215, US
    42.350723 -71.108227
  • Pikering Educational Resources LibraryBorrow it
    2 Silber Way, Boston, MA, 02215, US
    42.349804 -71.101425
  • School of Theology LibraryBorrow it
    745 Commonwealth Avenue, 2nd Floor, Boston, MA, 02215, US
    42.350494 -71.107235
  • Science & Engineering LibraryBorrow it
    38 Cummington Mall, Boston, MA, 02215, US
    42.348472 -71.102257
  • Stone Science LibraryBorrow it
    675 Commonwealth Avenue, Boston, MA, 02445, US
    42.350103 -71.103784
Processing Feedback ...