The Resource Molecular Recognition of DNA Double Helix : Gene Regulation and Photochemistry of BrU Substituted DNA, by Abhijit Saha, (electronic resource)

Molecular Recognition of DNA Double Helix : Gene Regulation and Photochemistry of BrU Substituted DNA, by Abhijit Saha, (electronic resource)

Label
Molecular Recognition of DNA Double Helix : Gene Regulation and Photochemistry of BrU Substituted DNA
Title
Molecular Recognition of DNA Double Helix
Title remainder
Gene Regulation and Photochemistry of BrU Substituted DNA
Statement of responsibility
by Abhijit Saha
Creator
Contributor
Author
Provider
Subject
Language
eng
Summary
In this book, the molecular recognition of DNA using small molecules is discussed, with a study of the photochemistry of BrU-labeled DNA. The purposes of the study were to develop small molecules for regenerative medicine, to develop a method to detect the recognition site of small molecules, and to detect the most important biological phenomena using the photochemistry of BrU-labeled DNA. The study began with the design and development of small molecules that can induce pluripotency genes. To deal with the important issue of cell permeability of the original compound, a new analogue of the original with improved gene expression was designed and synthesized. Using the photochemistry of BrU-labeled DNA, crucial biological phenomena such as cooperativity between transcription factors were detected. For the first time, the cooperativity was examined by excess electron transfer assay. DNA was also studied very carefully in order to understand the mechanism of the double-strand break in the UVA micro-irradiation technique. The mechanism of the double strand remained untouched. Nevertheless, the double-strand break mechanism was clearly demonstrated by Hoechst dye, as shown in this book.
Member of
http://library.link/vocab/creatorName
Saha, Abhijit
Image bit depth
0
LC call number
QD241-441
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
SpringerLink
Series statement
Springer Theses, Recognizing Outstanding Ph.D. Research,
http://library.link/vocab/subjectName
  • Chemistry
  • Bioorganic chemistry
  • Nucleic acids
  • Regenerative medicine
  • Tissue engineering
  • Chemistry
  • Bioorganic Chemistry
  • Nucleic Acid Chemistry
  • Regenerative Medicine/Tissue Engineering
Label
Molecular Recognition of DNA Double Helix : Gene Regulation and Photochemistry of BrU Substituted DNA, by Abhijit Saha, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
1. Overview of DNA minor groove binding synthetic small molecules and photochemistry of BrU substituted DNA -- 2. Synthesis and Biological Evaluation of Targeted Transcriptional Activator with HDAC8 Inhibitory Activity -- 3. Chemical Modification of a Synthetic Small Molecule Boosts its Biological Efficacy against Pluripotency Genes in Mouse Fibroblast -- 4. Development of a novel photochemical detection technique for the analysis of polyamide binding sites -- 5. Examining cooperative binding of Sox2 on DC5 regulatory element upon complex formation with Pax6 through excess electron transfer assay -- 6.UVA irradiation of BrU-substituted DNA in the presence of Hoechst 33258.
Dimensions
unknown
Extent
XVI, 114 p. 58 illus., 50 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9789811087462
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-981-10-8746-2
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-981-10-8746-2
Label
Molecular Recognition of DNA Double Helix : Gene Regulation and Photochemistry of BrU Substituted DNA, by Abhijit Saha, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
1. Overview of DNA minor groove binding synthetic small molecules and photochemistry of BrU substituted DNA -- 2. Synthesis and Biological Evaluation of Targeted Transcriptional Activator with HDAC8 Inhibitory Activity -- 3. Chemical Modification of a Synthetic Small Molecule Boosts its Biological Efficacy against Pluripotency Genes in Mouse Fibroblast -- 4. Development of a novel photochemical detection technique for the analysis of polyamide binding sites -- 5. Examining cooperative binding of Sox2 on DC5 regulatory element upon complex formation with Pax6 through excess electron transfer assay -- 6.UVA irradiation of BrU-substituted DNA in the presence of Hoechst 33258.
Dimensions
unknown
Extent
XVI, 114 p. 58 illus., 50 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9789811087462
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-981-10-8746-2
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-981-10-8746-2

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