Coverart for item
The Resource NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens : A Novel NMR-Tool for Natural Product Detection, by Martin Lorenz Stein, (electronic resource)

NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens : A Novel NMR-Tool for Natural Product Detection, by Martin Lorenz Stein, (electronic resource)

Label
NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens : A Novel NMR-Tool for Natural Product Detection
Title
NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens
Title remainder
A Novel NMR-Tool for Natural Product Detection
Statement of responsibility
by Martin Lorenz Stein
Creator
Contributor
Author
Provider
Subject
Language
eng
Summary
Martin Stein's thesis describes a novel methodology for natural product discovery. Due to its high degree of reproducibility, robustness and sensitivity, the technique can be utilized to detect even trace amounts of bioactive substances in heterogeneous matrices such as fermentation broths or crude organic extracts. This research is thus relevant for a large number of researchers working in natural product discovery. Applications of this novel NMR-based approach include suitable environmental triggers for the induction of biosynthetic machineries. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core particle from the insect pathogen photorhabdus luminescens. This thesis has led to a number of publications in high-impact journals
Member of
http://library.link/vocab/creatorName
Stein, Martin Lorenz
Image bit depth
0
LC call number
QD95-96
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
SpringerLink
Series statement
Springer Theses, Recognizing Outstanding Ph.D. Research,
http://library.link/vocab/subjectName
  • Chemistry
  • Spectroscopy
  • Bioorganic chemistry
  • Biochemistry
  • Chemistry
  • Spectroscopy/Spectrometry
  • Biochemistry, general
  • Bioorganic Chemistry
Label
NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens : A Novel NMR-Tool for Natural Product Detection, by Martin Lorenz Stein, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Dimensions
unknown
Extent
XVI, 71 p. 28 illus., 24 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319079141
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-3-319-07914-1
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-07914-1
Label
NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens : A Novel NMR-Tool for Natural Product Detection, by Martin Lorenz Stein, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Dimensions
unknown
Extent
XVI, 71 p. 28 illus., 24 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319079141
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-3-319-07914-1
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-07914-1

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