The Resource Nanoscale Imaging and Characterisation of Amyloid-β, by Claire Louisa Tinker-Mill, (electronic resource)

Nanoscale Imaging and Characterisation of Amyloid-β, by Claire Louisa Tinker-Mill, (electronic resource)

Label
Nanoscale Imaging and Characterisation of Amyloid-β
Title
Nanoscale Imaging and Characterisation of Amyloid-β
Statement of responsibility
by Claire Louisa Tinker-Mill
Creator
Contributor
Author
Provider
Subject
Language
eng
Summary
This thesis presents a method for reliably and robustly producing samples of amyloid-β (Aβ) by capturing them at various stages of aggregation, as well as the results of subsequent imaging with various atomic force microscopy (AFM) methods, all of which add value to the data gathered by collecting information on the peptide’s nanomechanical, elastic, thermal or spectroscopical properties. Amyloid-β (Aβ) undergoes a hierarchy of aggregation following a structural transition, making it an ideal subject of study using scanning probe microscopy (SPM), dynamic light scattering (DLS) and other physical techniques. By imaging samples of Aβ with Ultrasonic Force Microscopy, a detailed substructure to the morphology is revealed, which correlates well with the most advanced cryo-EM work. Early stage work in the area of thermal and spectroscopical AFM is also presented, and indicates the promise these techniques may hold for imaging sensitive and complex biological materials. This thesis demonstrates that physical techniques can be highly complementary when studying the aggregation of amyloid peptides, and allow the detection of subtle differences in their aggregation processes
Member of
http://library.link/vocab/creatorName
Tinker-Mill, Claire Louisa
Image bit depth
0
LC call number
  • QC450-467
  • QC718.5.S6
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
SpringerLink
Series statement
Springer Theses, Recognizing Outstanding Ph.D. Research,
http://library.link/vocab/subjectName
  • Physics
  • Molecular biology
  • Neurology
  • Amorphous substances
  • Complex fluids
  • Spectroscopy
  • Microscopy
  • Nanotechnology
  • Physics
  • Spectroscopy and Microscopy
  • Soft and Granular Matter, Complex Fluids and Microfluidics
  • Molecular Medicine
  • Neurology
  • Nanotechnology
Label
Nanoscale Imaging and Characterisation of Amyloid-β, by Claire Louisa Tinker-Mill, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction -- Literature Review and Theoretical Concepts -- Experimental Methodology -- Substrate Development of the Imaging of Amyloid Proteins with SPM Methods -- Scanning Probe Microscopy Methods of Imaging Amyloid Peptides During the Aggregation Process -- Spectroscopy and Thermal SPM Methods of Studying Aβ1:42 -- The Application of Biophysical Techniques to the Study of the Inhibition of Aggregation of Aβ Using PINPs Liposomes -- Conclusion and Future Perspectives
Dimensions
unknown
Extent
XX, 149 p. 59 illus., 14 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319395340
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-319-39534-0
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-39534-0
Label
Nanoscale Imaging and Characterisation of Amyloid-β, by Claire Louisa Tinker-Mill, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction -- Literature Review and Theoretical Concepts -- Experimental Methodology -- Substrate Development of the Imaging of Amyloid Proteins with SPM Methods -- Scanning Probe Microscopy Methods of Imaging Amyloid Peptides During the Aggregation Process -- Spectroscopy and Thermal SPM Methods of Studying Aβ1:42 -- The Application of Biophysical Techniques to the Study of the Inhibition of Aggregation of Aβ Using PINPs Liposomes -- Conclusion and Future Perspectives
Dimensions
unknown
Extent
XX, 149 p. 59 illus., 14 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319395340
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-319-39534-0
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-39534-0

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