The Resource Novel developments in stem cell mobilization : focus on CXCR4, Stefan Fruehauf, W. Jens Zeller, Gary Calandra, editors, (electronic resource)

Novel developments in stem cell mobilization : focus on CXCR4, Stefan Fruehauf, W. Jens Zeller, Gary Calandra, editors, (electronic resource)

Label
Novel developments in stem cell mobilization : focus on CXCR4
Title
Novel developments in stem cell mobilization
Title remainder
focus on CXCR4
Statement of responsibility
Stefan Fruehauf, W. Jens Zeller, Gary Calandra, editors
Contributor
Provider
Subject
Genre
Language
eng
Summary
Recently, the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development of effective antagonists. One antagonist, plerixafor, is now clinically approved for stem cell mobilization of lymphoma and myeloma patients. This progress allows patients to receive potentially life-saving treatment which could not have been administered otherwise. Through early clinical studies it was recognized that CXCR4 antagonists also mobilize malignant hematopoietic cells, i.e. leukemia cells. In preclinical studies, a sensitization of mobilized leukemic cells to standard cytotoxic chemotherapy could be shown. CXCR4 antagonists are an exciting new class of compounds which are also used for the mobilization of angiogenic cells or for the treatment of solid tumors. This book provides concise reviews of novel developments, as well as possible future developments on CXCR4
Cataloging source
GW5XE
Image bit depth
0
LC call number
QH588.S83
LC item number
N68 2012
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
  • SpringerLink
  • Fruehauf, Stefan
  • Zeller, W. J
  • Calandra, Gary
http://library.link/vocab/subjectName
  • Stem cells
  • Cancer
  • MEDICAL / Research
  • Biomedicine
  • Cancer Research
  • Pharmacology/Toxicology
  • Hematopoietic Stem Cell Mobilization
  • Neoplasms
Label
Novel developments in stem cell mobilization : focus on CXCR4, Stefan Fruehauf, W. Jens Zeller, Gary Calandra, editors, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Preface -- Preclinical Experience with AMD3100 for Mobilization of Hematopoietic Stem and Progenitor Cells -- Molecular Pharmacology of CXCR4 Inhibition -- Combination Strategies for Stem Cell Mobilization Targeting CXCR4 and S1P Receptors -- Should We Stay Or Should We Go Now? Cell Adhesion and Mobilization Pathways of Hematopoietic Cellls -- Role of the CXCR4/CXCL12 Axis in Hematopoietic Stem Cell Trafficking -- Early Studies of AMD3100/Plerixafor in Healthy Volunteers -- The Current Role of Plerixafor in Stem Cell Mobilization for Hematopoietic Stem Cell Transplantation -- Relevance and Clinical Implications of Tumor Cell Mobilization in Autologous Transplantation of Multiple Myeloma and non Hodgkin's lymphoma -- Plerixafor – Data from the Compassionate Use Program -- Stem Cell Mobilization with Chemomobilization plus Plerixafor in Hard-To-Mobilize Patients – The Experience at Kuopio University Hospital, Finland -- Blood Stem Cell Mobilization in Solid Tumors - Experience with Plerixafor and Alternative Ways of Hematopoietic Stem Cell Mobilization -- Mobilization with Chemotherapy+G-CSF+Plerixafor in Europe- the Italian experience -- Experience with Plerixafor in Poor Mobilizers -- CXCR4 Antagonists -- Application of CXCR4-Inhibitors in Leukemia -- CXCR4 Antagonists for the Treatment of CML -- Targeting CXCR4 in Chronic Lymphocytic Leukemia (CLL): Preclinical Rationale and Early Clinical Experience -- CXCR4-Blockade for Treatment of Breast Cancer -- Molecular Imaging of CXCR4 Receptor Expression in Tumors -- Potential Use of CXCR4 Antagonists to Mobilize Endothelial and Mesenchymal Stem Cells -- Strategies to Enhance Hematopoietic Stem Cell Engraftment Following Transplantation -- Mobilization for Gene Therapy -- Index
Dimensions
unknown
Extent
1 online resource (xiv, 496 p.)
File format
multiple file formats
Form of item
  • online
  • electronic
Isbn
9781461419600
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-1-4614-1960-0
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (OCoLC)777947224
  • (OCoLC)ocn777947224
Label
Novel developments in stem cell mobilization : focus on CXCR4, Stefan Fruehauf, W. Jens Zeller, Gary Calandra, editors, (electronic resource)
Publication
Antecedent source
mixed
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Preface -- Preclinical Experience with AMD3100 for Mobilization of Hematopoietic Stem and Progenitor Cells -- Molecular Pharmacology of CXCR4 Inhibition -- Combination Strategies for Stem Cell Mobilization Targeting CXCR4 and S1P Receptors -- Should We Stay Or Should We Go Now? Cell Adhesion and Mobilization Pathways of Hematopoietic Cellls -- Role of the CXCR4/CXCL12 Axis in Hematopoietic Stem Cell Trafficking -- Early Studies of AMD3100/Plerixafor in Healthy Volunteers -- The Current Role of Plerixafor in Stem Cell Mobilization for Hematopoietic Stem Cell Transplantation -- Relevance and Clinical Implications of Tumor Cell Mobilization in Autologous Transplantation of Multiple Myeloma and non Hodgkin's lymphoma -- Plerixafor – Data from the Compassionate Use Program -- Stem Cell Mobilization with Chemomobilization plus Plerixafor in Hard-To-Mobilize Patients – The Experience at Kuopio University Hospital, Finland -- Blood Stem Cell Mobilization in Solid Tumors - Experience with Plerixafor and Alternative Ways of Hematopoietic Stem Cell Mobilization -- Mobilization with Chemotherapy+G-CSF+Plerixafor in Europe- the Italian experience -- Experience with Plerixafor in Poor Mobilizers -- CXCR4 Antagonists -- Application of CXCR4-Inhibitors in Leukemia -- CXCR4 Antagonists for the Treatment of CML -- Targeting CXCR4 in Chronic Lymphocytic Leukemia (CLL): Preclinical Rationale and Early Clinical Experience -- CXCR4-Blockade for Treatment of Breast Cancer -- Molecular Imaging of CXCR4 Receptor Expression in Tumors -- Potential Use of CXCR4 Antagonists to Mobilize Endothelial and Mesenchymal Stem Cells -- Strategies to Enhance Hematopoietic Stem Cell Engraftment Following Transplantation -- Mobilization for Gene Therapy -- Index
Dimensions
unknown
Extent
1 online resource (xiv, 496 p.)
File format
multiple file formats
Form of item
  • online
  • electronic
Isbn
9781461419600
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-1-4614-1960-0
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (OCoLC)777947224
  • (OCoLC)ocn777947224

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