The Resource Phospholipases in Health and Disease, edited by Paramjit S. Tappia, Naranjan S. Dhalla, (electronic resource)

Phospholipases in Health and Disease, edited by Paramjit S. Tappia, Naranjan S. Dhalla, (electronic resource)

Label
Phospholipases in Health and Disease
Title
Phospholipases in Health and Disease
Statement of responsibility
edited by Paramjit S. Tappia, Naranjan S. Dhalla
Creator
Contributor
Editor
Provider
Subject
Language
eng
Summary
Phospholipases generate lipid signaling molecules through their hydrolytic action on phospholipids and are known to regulate function of a variety of cells under normal and diseased conditions. While several physiological, biochemical and molecular techniques have identified key players involved in different disease processes, phospholipases have also emerged as critical players in the pathogenesis of a number of different diseases including cancer and heart disease. In addition, phospholipases are also implicated in such conditions as brain disorder/injury, kidney and immune cell dysfunction. Phospholipases in Health and Disease is a compilation of review articles dedicated to the study of the field with respect to biochemical and molecular mechanisms of normal and abnormal cell function. The wide range of area covered here is of interest to basic research scientists, clinicians and graduate students, who are engaged in studying pathophysiological basis of a variety of diseases. Furthermore, this book highlights the potential of the different phospholipases as therapeutic targets as well as part of prevention strategies. Twenty three articles in this book are organized in four sections that are designed to emphasize the most characterized forms of the phospholipases in mammalian cells. The first section discusses general aspect of phospholipases. Section two covers the role and function of phospholipase A in different pathophysiological conditions. The third section is focussed on phospholipase C which is believed to play a central role in transmembrane signaling. The final section covers phospholipase D which is present in a variety of different cells. The book illustrates that the activation of phospholipases is of fundamental importance in signal transduction affecting cell function. Overall, this book discusses the diverse mechanisms of phospholipase mediated signal transduction in different pathophysiological conditions and raises the possibility of specific forms of phospholipases serving as novel targets for drug development
Member of
http://library.link/vocab/creatorName
Tappia, Paramjit S
Image bit depth
0
LC call number
  • QH345
  • QD415-436
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
  • Dhalla, Naranjan S.
  • SpringerLink
Series statement
Advances in Biochemistry in Health and Disease
Series volume
10
http://library.link/vocab/subjectName
  • Life sciences
  • Medicine
  • Neurosciences
  • Enzymes
  • Lipids
  • Cell receptors
  • Cell membranes
  • Life Sciences
  • Lipidology
  • Molecular Medicine
  • Enzymology
  • Receptors
  • Neurosciences
  • Membrane Biology
Label
Phospholipases in Health and Disease, edited by Paramjit S. Tappia, Naranjan S. Dhalla, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Phospholipases in Health and Disease -- Role of Phospholipases in Regulation of Cardiolipin Biosynthesis and Remodelling in the Heart and Mammalian Cells -- Role of Phospholipases and Oxidized Phospholipids in Inflammation -- Phospholipases in Cardiovascular Disease -- The Structures and Functions of Intracellular Phospholipase A1 Family Proteins -- Phospholipase A and Breast Cancer -- Pathophysiological Aspects of Lipoprotein Associated Phospholipase A2: A Brief Overview -- Phospholipase A2 Activity Exhibited by a Bacterial Virulence Protein that Enters and Operates within a Variety of Host Cells -- Expression and Role of Phospholipase A2 in Central Nervous System Injury and Disease -- Cytoplasmic Phospholipase A2 and Autotaxin Inhibitors as Potential Radiosensitizers -- Phospholipase A2 Enzymes: Potential Targets for Therapy -- The Role of Phospholipase C Isozymes in Cellular Homeostasis -- Phospholipase C in the Immune Cell -- Phosphoinositide-specific Phospholipase C Enzymes and Cognitive Development and Decline -- Where life begins: Sperm PLCz in mammalian egg activation and implications in male infertility -- Oocyte Activation and Phospholipase C zeta (PLCζ): Male Infertility and Implications for Therapeutic Intervention -- Phospholipase C Signaling in Heart Disease -- Activation of Phospholipase C in Cardiac Hypertrophy -- The Protective Effect of Phospholipase C From Cardiac Ischemia-Reperfusion Injury -- Role of Phospholipase C in Cardioprotection During Oxidative Stress -- Mammalian Phospholipase D: Structure, Regulation and Physiological Functions of Phospholipase D and its Link to Pathology -- Emerging Roles of Phospholipase D in Pathophysiological Signaling -- Alterations in Phospholipase D During the Development of Myocardial Disease
Dimensions
unknown
Extent
XIX, 410 p. 69 illus., 53 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9781493904648
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-4939-0464-8
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-1-4939-0464-8
Label
Phospholipases in Health and Disease, edited by Paramjit S. Tappia, Naranjan S. Dhalla, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Phospholipases in Health and Disease -- Role of Phospholipases in Regulation of Cardiolipin Biosynthesis and Remodelling in the Heart and Mammalian Cells -- Role of Phospholipases and Oxidized Phospholipids in Inflammation -- Phospholipases in Cardiovascular Disease -- The Structures and Functions of Intracellular Phospholipase A1 Family Proteins -- Phospholipase A and Breast Cancer -- Pathophysiological Aspects of Lipoprotein Associated Phospholipase A2: A Brief Overview -- Phospholipase A2 Activity Exhibited by a Bacterial Virulence Protein that Enters and Operates within a Variety of Host Cells -- Expression and Role of Phospholipase A2 in Central Nervous System Injury and Disease -- Cytoplasmic Phospholipase A2 and Autotaxin Inhibitors as Potential Radiosensitizers -- Phospholipase A2 Enzymes: Potential Targets for Therapy -- The Role of Phospholipase C Isozymes in Cellular Homeostasis -- Phospholipase C in the Immune Cell -- Phosphoinositide-specific Phospholipase C Enzymes and Cognitive Development and Decline -- Where life begins: Sperm PLCz in mammalian egg activation and implications in male infertility -- Oocyte Activation and Phospholipase C zeta (PLCζ): Male Infertility and Implications for Therapeutic Intervention -- Phospholipase C Signaling in Heart Disease -- Activation of Phospholipase C in Cardiac Hypertrophy -- The Protective Effect of Phospholipase C From Cardiac Ischemia-Reperfusion Injury -- Role of Phospholipase C in Cardioprotection During Oxidative Stress -- Mammalian Phospholipase D: Structure, Regulation and Physiological Functions of Phospholipase D and its Link to Pathology -- Emerging Roles of Phospholipase D in Pathophysiological Signaling -- Alterations in Phospholipase D During the Development of Myocardial Disease
Dimensions
unknown
Extent
XIX, 410 p. 69 illus., 53 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9781493904648
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-4939-0464-8
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-1-4939-0464-8

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