Coverart for item
The Resource Purification of Peptides in High-Complexity Arrays : A New Method for the Specific Surface Exchange and Purification of Entire Peptide Libraries, by Christopher Schirwitz, (electronic resource)

Purification of Peptides in High-Complexity Arrays : A New Method for the Specific Surface Exchange and Purification of Entire Peptide Libraries, by Christopher Schirwitz, (electronic resource)

Label
Purification of Peptides in High-Complexity Arrays : A New Method for the Specific Surface Exchange and Purification of Entire Peptide Libraries
Title
Purification of Peptides in High-Complexity Arrays
Title remainder
A New Method for the Specific Surface Exchange and Purification of Entire Peptide Libraries
Statement of responsibility
by Christopher Schirwitz
Creator
Contributor
Author
Provider
Subject
Language
eng
Summary
Christopher Schirwitz's thesis focuses on improving the quality of in situ synthesized high-complexity peptide micro arrays. Micro arrays containing proteins or small protein fragments in the form of peptides have become of great interest in proteomic research. With the help of these microarrays a large number of potential target molecules can be screened for interaction with a probe in a short timeframe. However, protein and peptide micro arrays are still lagging behind oligonucleotide arrays in terms of density, quality and manufacturing costs. A new approach developed at the German Cancer Research Center (DKFZ) has improved the synthesis of high-density peptide arrays. The current technology is capable of producing arrays with up to 40,000 different peptides per square cm by means of micro particle-based solid phase peptide synthesis. However, in situ synthesis approaches bear a conceptual disadvantage: The quality of the peptides is dependent on the efficiency of the synthesis so that peptide fragments are present in the resulting array among the desired full-length peptides. In peptide-protein interaction studies such peptide fragments. The central achievement of this thesis is the development of a new method allowing for the fast one-step purification of entire arrays without loss of resolution or spatial information. Christopher Schirwitz's work has resulted in a number of publications in high ranking journals
Member of
http://library.link/vocab/creatorName
Schirwitz, Christopher
Image bit depth
0
LC call number
QD241-441
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
SpringerLink
Series statement
Springer Theses, Recognizing Outstanding Ph.D. Research,
http://library.link/vocab/subjectName
  • Chemistry
  • Bioorganic chemistry
  • Chemistry, Physical organic
  • Biochemistry
  • Chemistry
  • Bioorganic Chemistry
  • Protein Science
  • Physical Chemistry
Label
Purification of Peptides in High-Complexity Arrays : A New Method for the Specific Surface Exchange and Purification of Entire Peptide Libraries, by Christopher Schirwitz, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Introduction -- Concept & State-of-the-Art -- Results & Discussion -- Conclusion -- Materials & Methods
Dimensions
unknown
Extent
XIII, 132 p. 59 illus., 53 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319008073
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-3-319-00807-3
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-00807-3
Label
Purification of Peptides in High-Complexity Arrays : A New Method for the Specific Surface Exchange and Purification of Entire Peptide Libraries, by Christopher Schirwitz, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Introduction -- Concept & State-of-the-Art -- Results & Discussion -- Conclusion -- Materials & Methods
Dimensions
unknown
Extent
XIII, 132 p. 59 illus., 53 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319008073
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-3-319-00807-3
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-00807-3

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