The Resource Stereoselective Desymmetrization Methods in the Assembly of Complex Natural Molecules, by Robert.J Sharpe, (electronic resource)

Stereoselective Desymmetrization Methods in the Assembly of Complex Natural Molecules, by Robert.J Sharpe, (electronic resource)

Label
Stereoselective Desymmetrization Methods in the Assembly of Complex Natural Molecules
Title
Stereoselective Desymmetrization Methods in the Assembly of Complex Natural Molecules
Statement of responsibility
by Robert.J Sharpe
Creator
Contributor
Author
Provider
Subject
Language
eng
Summary
This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials – the shortest synthesis to date. He subsequently demonstrates the flexibility of this approach in SAR investigations by highlighting the preparation of twenty-five unique pactamycin structural congeners. For paspaline, the author develops a biocatalytic desymmetrization strategy that allows the highly controlled synthesis of core stereochemistry and provides a platform for the development of new conceptual disconnections in the synthesis of "steroid-like" natural products. This thesis offers a valuable resource for students embarking on a PhD in total synthesis
Member of
http://library.link/vocab/creatorName
Sharpe, Robert.J
Image bit depth
0
LC call number
QD415-436
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
SpringerLink
Series statement
Springer Theses, Recognizing Outstanding Ph.D. Research,
http://library.link/vocab/subjectName
  • Chemistry
  • Organic chemistry
  • Chemical engineering
  • Medicinal chemistry
  • Chemistry
  • Organic Chemistry
  • Medicinal Chemistry
  • Industrial Chemistry/Chemical Engineering
Label
Stereoselective Desymmetrization Methods in the Assembly of Complex Natural Molecules, by Robert.J Sharpe, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Asymmetric Synthesis Of The Aminocyclitol Pactamycin, A Universal Translocation Inhibitor -- Preparation And Biological Evaluation Of Synthetic and Polymer-Encapsulated Congeners of the Antitumor Agent Pactamycin: Insight Into Functional Group Effects and Biological Activity -- Inception and Development of a Global and Local Desymmetrization Approach to the Synthesis of Steroidal Alkaloids: Stereocontrolled Total Synthesis of Paspaline
Dimensions
unknown
Extent
XXIX, 266 p. 367 illus., 11 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319390253
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-3-319-39025-3
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-39025-3
Label
Stereoselective Desymmetrization Methods in the Assembly of Complex Natural Molecules, by Robert.J Sharpe, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Asymmetric Synthesis Of The Aminocyclitol Pactamycin, A Universal Translocation Inhibitor -- Preparation And Biological Evaluation Of Synthetic and Polymer-Encapsulated Congeners of the Antitumor Agent Pactamycin: Insight Into Functional Group Effects and Biological Activity -- Inception and Development of a Global and Local Desymmetrization Approach to the Synthesis of Steroidal Alkaloids: Stereocontrolled Total Synthesis of Paspaline
Dimensions
unknown
Extent
XXIX, 266 p. 367 illus., 11 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319390253
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-3-319-39025-3
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-3-319-39025-3

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