The Resource Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells, by Xiaoyang Zhao, (electronic resource)

Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells, by Xiaoyang Zhao, (electronic resource)

Label
Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells
Title
Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells
Statement of responsibility
by Xiaoyang Zhao
Creator
Contributor
Author
Provider
Subject
Language
eng
Summary
Stem cells have the ability to differentiate into all types of cells within the body, thus have great therapeutic potential for regenerative medicine to treat complicated disorders, like Parkinson’s disease and spinal cord injury. There will also be many applications in drug development. However, several roadblocks, such as safety issues and low efficiency of pluripotent stem cell (PSC) line derivation need to be resolved before their clinical application. This thesis focuses on these two areas, so as to find methods to overcome the limitation. It covers deriving embryonic stem cells (ESCs) from several different species, and reports an efficient system to generate induced pluripotent stem cells (iPSCs), and the first iPSC mice in the world. The results in this thesis confirm that somatic cells can be fully reprogrammed with the four Yamanaka factors. In addition, we have found that the Dlk1-Dio3 region can be a potential molecular marker to distinguish the fully reprogrammed iPSCs from partially reprogrammed ones. All of these results will help improve the safety of PSCs in the clinical applications, and increase the current low induction efficiency of their production
Member of
http://library.link/vocab/creatorName
Zhao, Xiaoyang
Image bit depth
0
LC call number
QH588.S83
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
SpringerLink
Series statement
Springer Theses, Recognizing Outstanding Ph.D. Research,
http://library.link/vocab/subjectName
  • Life sciences
  • Stem cells
  • Cell culture
  • Developmental biology
  • Life Sciences
  • Stem Cells
  • Cell Culture
  • Regenerative Medicine/Tissue Engineering
  • Developmental Biology
Label
Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells, by Xiaoyang Zhao, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Abstract -- Introduction -- Establishment of highly efficient somatic cell reprogramming system to generate iPSC lines- Establishment of highly efficient somatic cell reprogramming system and establishment of iPSC lines -- Pluripotency of iPSC and underlining mechanism -- Developmental potential of mouse iPSC -- Conclusions
Dimensions
unknown
Extent
XV, 92 p. 21 illus., 18 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9789401788199
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-94-017-8819-9
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-94-017-8819-9
Label
Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells, by Xiaoyang Zhao, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Abstract -- Introduction -- Establishment of highly efficient somatic cell reprogramming system to generate iPSC lines- Establishment of highly efficient somatic cell reprogramming system and establishment of iPSC lines -- Pluripotency of iPSC and underlining mechanism -- Developmental potential of mouse iPSC -- Conclusions
Dimensions
unknown
Extent
XV, 92 p. 21 illus., 18 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9789401788199
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-94-017-8819-9
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-94-017-8819-9

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