The Resource Targeting Protein-Protein Interactions by Small Molecules, edited by Chunquan Sheng, Gunda I. Georg, (electronic resource)

Targeting Protein-Protein Interactions by Small Molecules, edited by Chunquan Sheng, Gunda I. Georg, (electronic resource)

Label
Targeting Protein-Protein Interactions by Small Molecules
Title
Targeting Protein-Protein Interactions by Small Molecules
Statement of responsibility
edited by Chunquan Sheng, Gunda I. Georg
Contributor
Editor
Provider
Subject
Language
eng
Summary
This book comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors. The first part discusses various discovery strategies for small molecule PPI inhibitors, such as high throughput screening, hot spot-based design, computational approaches, and fragment-based design. The second part presents recent advances in small molecule inhibitors, focusing on clinical candidates and new PPI targets. This book has broad appeal and is of significant interest to the pharmaceutical science and medicinal chemistry communities.
Image bit depth
0
LC call number
RS400-431
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
  • Sheng, Chunquan.
  • Georg, Gunda I.
  • SpringerLink
http://library.link/vocab/subjectName
  • Chemistry
  • Pharmaceutical technology
  • Bioorganic chemistry
  • Pharmaceutical chemistry
  • Proteins
  • Chemistry
  • Medicinal Chemistry
  • Pharmaceutical Sciences/Technology
  • Bioorganic Chemistry
  • Protein Science
Label
Targeting Protein-Protein Interactions by Small Molecules, edited by Chunquan Sheng, Gunda I. Georg, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Part 1 Current strategies for the discovery of small-molecule inhibitors of protein–protein interactions -- Overview of Protein-protein Interactions and Small Molecule Inhibitors under Clinical Development -- High throughput screening in the discovery of small molecule inhibitors of protein-protein interactions -- Hot Spot-Based Design of Small-Molecule Inhibitors for Protein–Protein Interactions -- Computational Methods Applicable to the Discovery of Small-Molecule Inhibitors of Protein-Protein Interactions -- Experimental Methods Used for Identifying Small-Molecule Inhibitors of Protein-protein Interaction -- Fragment-based Drug Discovery for Developing Inhibitors of Protein-protein Interactions -- Part 2 Case studies of small-molecule inhibitors of protein–protein interactions -- Small molecule inhibitors targeting new targets of protein-protein interactions -- The Development of New Spirooxindoles Targeting the p53-MDM2 Protein-Protein Interactions for Cancer Therapy -- Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein−Protein Interaction -- Discovery and development of Keap1-Nrf2 protein-protein interaction inhibitors -- BRDT Inhibitors for Male Contraceptive Drug Discovery: Current Status -- Targeting Protein-Protein Interactions in Small GTPases
Dimensions
unknown
Extent
XI, 329 p. 132 illus., 100 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9789811307737
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-981-13-0773-7
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-981-13-0773-7
Label
Targeting Protein-Protein Interactions by Small Molecules, edited by Chunquan Sheng, Gunda I. Georg, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Part 1 Current strategies for the discovery of small-molecule inhibitors of protein–protein interactions -- Overview of Protein-protein Interactions and Small Molecule Inhibitors under Clinical Development -- High throughput screening in the discovery of small molecule inhibitors of protein-protein interactions -- Hot Spot-Based Design of Small-Molecule Inhibitors for Protein–Protein Interactions -- Computational Methods Applicable to the Discovery of Small-Molecule Inhibitors of Protein-Protein Interactions -- Experimental Methods Used for Identifying Small-Molecule Inhibitors of Protein-protein Interaction -- Fragment-based Drug Discovery for Developing Inhibitors of Protein-protein Interactions -- Part 2 Case studies of small-molecule inhibitors of protein–protein interactions -- Small molecule inhibitors targeting new targets of protein-protein interactions -- The Development of New Spirooxindoles Targeting the p53-MDM2 Protein-Protein Interactions for Cancer Therapy -- Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein−Protein Interaction -- Discovery and development of Keap1-Nrf2 protein-protein interaction inhibitors -- BRDT Inhibitors for Male Contraceptive Drug Discovery: Current Status -- Targeting Protein-Protein Interactions in Small GTPases
Dimensions
unknown
Extent
XI, 329 p. 132 illus., 100 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9789811307737
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-981-13-0773-7
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-981-13-0773-7

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