The Resource The adrenergic system in cardiovascular physiology and pathophysiology, edited by: Giuseppe Rengo, (electronic resource)

The adrenergic system in cardiovascular physiology and pathophysiology, edited by: Giuseppe Rengo, (electronic resource)

Label
The adrenergic system in cardiovascular physiology and pathophysiology
Title
The adrenergic system in cardiovascular physiology and pathophysiology
Statement of responsibility
edited by: Giuseppe Rengo
Contributor
Issuing body
Subject
Language
  • eng
  • eng
Summary
Cardiovascular diseases pose an enormous clinical challenge, remaining the most common cause of death in the world. β-adrenoceptors play an important role on cardiac, vascular and/or endothelial function at a cellular level with relevant applications in several cardiovascular diseases, such as heart failure and hypertension. G protein–coupled receptors (GPCRs), including β-adrenergic receptors, constitute the most ubiquitous superfamily of plasma membrane receptors and represent the single most important type of therapeutic drug target. Sympathetic nervous system hyperactivity, which characterizes several cardiovascular diseases, such as heart failure and hypertension, as well as physiological ageing, has been proved to exert in the long-term detrimental effects in a wide range of cardiovascular diseases. Acutely, sympathetic hyperactivity represents the response to an insult to the myocardium, aiming to compensate for decreased cardiac output. This process involves the activation of beta-adrenergic receptors by catecholamine with consequent heart rate and cardiac contractility increase. However, long-term exposure of the heart to elevated norepinephrine and epinephrine levels, originating from sympathetic nerve endings and chromaffin cells of the adrenal gland, results in further progressive deterioration in cardiac structure and function. At the molecular level, sustained sympathetic nervous system hyperactivity is responsible for several alterations including altered beta-adrenergic receptor signaling and function (down-regulation/desensitization). Moreover, the detrimental effects of catecholamine affect also the function of different cell types including, but not limited to, endothelial cells, fibroblasts and smooth muscle cells. Thus, the success of beta-blocker therapy is due, at least in part, to the protection of the heart and the vasculature from the noxious effects of augmented catecholamine levels. The current research topic aims to support the progress towards understanding the role of sympathetic nervous system under physiological conditions, and the contribution of its hyperactivity in the pathogenesis and progression of cardiovascular diseases. The topic is open to original studies, descriptions of new methodologies, reviews and opinions
Member of
http://bibfra.me/vocab/relation/editorcontributor
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Illustrations
  • illustrations
  • charts
Index
no index present
Literary form
non fiction
Nature of contents
bibliography
http://library.link/vocab/relatedWorkOrContributorName
  • Rengo, Giuseppe
  • Frontiers Research Foundation
Series statement
  • Frontiers Research Topics
  • Frontiers in Physiology
http://library.link/vocab/subjectName
  • Cardiovascular system
  • Cardiovascular system
  • Cardiovascular system
Target audience
specialized
Label
The adrenergic system in cardiovascular physiology and pathophysiology, edited by: Giuseppe Rengo, (electronic resource)
Instantiates
Publication
Copyright
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Edition
Second edition.
Extent
1 online resource (78 pages)
Form of item
online
Governing access note
Open Access
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations; digital, PDF file(s).
System control number
(EXLCZ)993710000000631062
System details
  • Mode of access: internet via World Wide Web
  • System requirements: Adobe Acrobat or other PDF reader (latest version recommended), Internet Explorer or other browser (latest version recommended)
Label
The adrenergic system in cardiovascular physiology and pathophysiology, edited by: Giuseppe Rengo, (electronic resource)
Publication
Copyright
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Edition
Second edition.
Extent
1 online resource (78 pages)
Form of item
online
Governing access note
Open Access
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations; digital, PDF file(s).
System control number
(EXLCZ)993710000000631062
System details
  • Mode of access: internet via World Wide Web
  • System requirements: Adobe Acrobat or other PDF reader (latest version recommended), Internet Explorer or other browser (latest version recommended)

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