The Resource The impact of stereochemistry on drug development and use, [edited by] Hassan Y. Aboul-Enein and Irving W. Wainer

The impact of stereochemistry on drug development and use, [edited by] Hassan Y. Aboul-Enein and Irving W. Wainer

Label
The impact of stereochemistry on drug development and use
Title
The impact of stereochemistry on drug development and use
Statement of responsibility
[edited by] Hassan Y. Aboul-Enein and Irving W. Wainer
Contributor
Subject
Language
eng
Summary
The book explores analytical, pharmacological, and regulatory topics in dealing with the theory and practice of stereochemistry in the pharmarceutical industry today. This exciting, broad-appeal treatment extends from the analytical viewpoint in enantiomeric separation to the regulatory issues involved in the "racemate-versus-enantiomer" debate. The authors include numerous examples and case studies, and integrate material from a wide range of studies, publications, and workshops. The Impact of Stereochemistry on Drug Development and Use is an essential reference for medicinal and analytical chemists, pharmacologists, drug metabolism and pharmacokinetic scientists, and personnel of regulatory agencies. It is also a useful text for graduate students in stereochemistry, and for anyone who wants to keep up with the swift pace of change in this dynamic field
Member of
Cataloging source
DLC
Illustrations
illustrations
Index
index present
LC call number
RS429
LC item number
.I48 1997
Literary form
non fiction
Nature of contents
bibliography
NLM call number
  • 1997 I-481
  • QV 744
NLM item number
I31 1997
http://library.link/vocab/relatedWorkOrContributorName
  • Aboul-Enein, Hassan Y
  • Wainer, Irving W
http://library.link/vocab/subjectName
  • Chiral drugs
  • Chemistry, Pharmaceutical
  • Stereoisomerism
  • Molecular Conformation
  • Médicaments chiraux
  • Stéréoisomérie
  • Chimie analytique
  • Chiral drugs
  • Stéréochimie
  • Chiralité
  • Énantiomères
  • Médicaments
  • Énantiomères
  • Arzneimittel
  • Stereochemie
  • Struktur-Aktivitäts-Beziehung
Label
The impact of stereochemistry on drug development and use, [edited by] Hassan Y. Aboul-Enein and Irving W. Wainer
Instantiates
Publication
Note
  • Series no. on spine 134 [sic]
  • "A Wiley-Interscience publication."
Bibliography note
Includes bibliographical references and index
Carrier category
volume
Carrier category code
  • nc
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Chirality and drug hazards / Hassan Y. Aboul-Enein and Laila I. Abou Basha -- Stereochemistry in the drug development process : role of chirality as a determinant of drug action, metabolism, and toxicity / Thomas A. Baillie and Kathleen M. Schultz -- Stereochemical aspects of drug metabolism / Jonathan P. Mason and Andrew J. Hutt -- Some examples for stereoselective biotransformation of drugs / Gottfried Blaschke -- Kinetics of reactive phase II metabolites : stereochemical aspects of formation of epimeric acyl glucuronides and their reactivity / Hildegard Spahn-Langguth [and others] -- Studies on the stereoselectivity of the biologically important metabolism of alkene-alkene oxide (oxirane)-alkanediol / Dorothee Wistuba -- Chiral barbiturates : synthesis, chromatographic resolutions, and biological activity / Jacek Bojarski -- Ethambutol and tuerculosis, a neglected and confused chiral puzzle / Bernard Blessington -- Stereogenic elements of pharmaceutical compounds : some aspects on isomerism, resolution, and stereochemical integrity / Stig G. Allen Mark -- The importance of chiral separations in pharmaceuticals / Sut Ahuja -- Separation of optically active pharmaceuticals using capillary electrophoresis / Timothy J. Ward and Karen D. Ward -- Chiral recognition mechanism of polysaccharides chiral stationary phases / Eji Yashima and Yoshio Okamoto -- Michelle-mediated capillary electrophoretic separation of enantomeric compounds / Michael E. Swartz and Phyllis R. Brown -- Unified enantioselective chromatography involving chirasil-dex / Volker Schurig [and others] -- Derivatized cyclodextrins as chiral gas chromatographic stationary phases and their potential applications in the pharmaceutical industry / Weiyong Li and Thomas M. Rossi -- Chiral derivatization reagents in the bioanalysis of optically active drugs with chromophore-based detection / Ralf Büschges [and others] -- Circular dichroism spectroscopy in the analysis of chiral drugs / Piera Salvadori, Carlo Rosini, and Carlo Bertucci -- Circular Dichroism in the study of stereoselective binding of drugs to serum proteins / Carlo Bertucci, Piero Salvadori, and Enrico Domenici -- Current regulatory guidelines of stereoisomeric drugs : North American, European, and Japanese point of view / Sylvie Laganiére -- Enantioselective analysis and the regulation of chiral drugs / Michael Gross -- First pass phenomena : sources of stereoselectives and variabilities of concentration-time profiles after oral dosage / Hildegard Spahn-Langguth [and others] -- Gastrointestinal transport processes : potentials for stereoselectivities at substrate-specific and nonspecific epithelial transport systems / Peter Langguth -- Preparation of drug enantiomers by chromatographic resolution on chiral stationary phases / Eric Francotte
Dimensions
24 cm.
Extent
xxvii, 695 p.
Isbn
9780471596448
Isbn Type
(acid-free paper)
Lccn
96033491
Media category
unmediated
Media MARC source
rdamedia
Media type code
  • n
Other physical details
ill.
System control number
  • (OCoLC)35262289
  • (OCoLC)ocm35262289
Label
The impact of stereochemistry on drug development and use, [edited by] Hassan Y. Aboul-Enein and Irving W. Wainer
Publication
Note
  • Series no. on spine 134 [sic]
  • "A Wiley-Interscience publication."
Bibliography note
Includes bibliographical references and index
Carrier category
volume
Carrier category code
  • nc
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Chirality and drug hazards / Hassan Y. Aboul-Enein and Laila I. Abou Basha -- Stereochemistry in the drug development process : role of chirality as a determinant of drug action, metabolism, and toxicity / Thomas A. Baillie and Kathleen M. Schultz -- Stereochemical aspects of drug metabolism / Jonathan P. Mason and Andrew J. Hutt -- Some examples for stereoselective biotransformation of drugs / Gottfried Blaschke -- Kinetics of reactive phase II metabolites : stereochemical aspects of formation of epimeric acyl glucuronides and their reactivity / Hildegard Spahn-Langguth [and others] -- Studies on the stereoselectivity of the biologically important metabolism of alkene-alkene oxide (oxirane)-alkanediol / Dorothee Wistuba -- Chiral barbiturates : synthesis, chromatographic resolutions, and biological activity / Jacek Bojarski -- Ethambutol and tuerculosis, a neglected and confused chiral puzzle / Bernard Blessington -- Stereogenic elements of pharmaceutical compounds : some aspects on isomerism, resolution, and stereochemical integrity / Stig G. Allen Mark -- The importance of chiral separations in pharmaceuticals / Sut Ahuja -- Separation of optically active pharmaceuticals using capillary electrophoresis / Timothy J. Ward and Karen D. Ward -- Chiral recognition mechanism of polysaccharides chiral stationary phases / Eji Yashima and Yoshio Okamoto -- Michelle-mediated capillary electrophoretic separation of enantomeric compounds / Michael E. Swartz and Phyllis R. Brown -- Unified enantioselective chromatography involving chirasil-dex / Volker Schurig [and others] -- Derivatized cyclodextrins as chiral gas chromatographic stationary phases and their potential applications in the pharmaceutical industry / Weiyong Li and Thomas M. Rossi -- Chiral derivatization reagents in the bioanalysis of optically active drugs with chromophore-based detection / Ralf Büschges [and others] -- Circular dichroism spectroscopy in the analysis of chiral drugs / Piera Salvadori, Carlo Rosini, and Carlo Bertucci -- Circular Dichroism in the study of stereoselective binding of drugs to serum proteins / Carlo Bertucci, Piero Salvadori, and Enrico Domenici -- Current regulatory guidelines of stereoisomeric drugs : North American, European, and Japanese point of view / Sylvie Laganiére -- Enantioselective analysis and the regulation of chiral drugs / Michael Gross -- First pass phenomena : sources of stereoselectives and variabilities of concentration-time profiles after oral dosage / Hildegard Spahn-Langguth [and others] -- Gastrointestinal transport processes : potentials for stereoselectivities at substrate-specific and nonspecific epithelial transport systems / Peter Langguth -- Preparation of drug enantiomers by chromatographic resolution on chiral stationary phases / Eric Francotte
Dimensions
24 cm.
Extent
xxvii, 695 p.
Isbn
9780471596448
Isbn Type
(acid-free paper)
Lccn
96033491
Media category
unmediated
Media MARC source
rdamedia
Media type code
  • n
Other physical details
ill.
System control number
  • (OCoLC)35262289
  • (OCoLC)ocm35262289

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