The Resource Therapeutic kinase inhibitors, Ingo K. Mellinghoff, Charles L. Sawyers, editors ; responsible series editor: Peter K. Vogt, (electronic resource)

Therapeutic kinase inhibitors, Ingo K. Mellinghoff, Charles L. Sawyers, editors ; responsible series editor: Peter K. Vogt, (electronic resource)

Label
Therapeutic kinase inhibitors
Title
Therapeutic kinase inhibitors
Statement of responsibility
Ingo K. Mellinghoff, Charles L. Sawyers, editors ; responsible series editor: Peter K. Vogt
Contributor
Provider
Subject
Language
eng
Summary
Cancer drug development is currently undergoing a profound shift. Drugs targeting fundamental cellular processes such DNA-replication and microtubule function, often referred to as “chemotherapy” and still the backbone of most cancer treatment regimens, are increasingly being complemented by or replaced with kinase inhibitors. This new class of drugs targets enzymes which provide growth and survival signals to cancer cells by transferring phosphate groups from Adenosine-5'-triphosphate (ATP) to other proteins, lipids, nucleotides, and carbohydrates. This book summarizes the current state of kinase inhibitor therapy for cancer. Successful drug development relies on the expertise and dedication of many experts. To reflect this team approach to finding new kinase inhibitors and defining their optimal use for cancer treatment, the editors invited experts in academia and pharmaceutical industry to share their insights into various aspects of this process, ranging from the first chemical screens, to preclinical testing and disease-focused clinical drug development. The editors hope these lessons will be instructive for the novice as well as the expert
Member of
Cataloging source
GW5XE
Image bit depth
0
LC call number
QR1
LC item number
.E6 v.355 2012eb
Literary form
non fiction
Nature of contents
dictionaries
NLM call number
  • W1
  • QZ 267
NLM item number
CU82K v.355 2012
http://library.link/vocab/relatedWorkOrContributorName
  • SpringerLink
  • Mellinghoff, Ingo K
  • Sawyers, Charles L
Series statement
Current Topics in Microbiology and Immunology,
Series volume
355
http://library.link/vocab/subjectName
  • Cancer
  • Antineoplastic agents
  • MEDICAL / Pharmacology
  • Antineoplastic agents
  • Cancer
  • Neoplasms
  • Protein Kinase Inhibitors
  • Antineoplastic Agents
  • Drug Discovery
  • Adenosine Triphosphate
Label
Therapeutic kinase inhibitors, Ingo K. Mellinghoff, Charles L. Sawyers, editors ; responsible series editor: Peter K. Vogt, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Bibliography note
Includes bibliographical references and index
Color
not applicable
Contents
  • Targeting Oncogenic BRAF in Human Cancer
  • Christine A. Pratilas, Feng Xing, David B. Solit
  • Beyond BRAF in Melanoma
  • Adil Daud, Boris C. Bastian
  • JAK-Mutant Myeloproliferative Neoplasms
  • Ross L. Levine
  • Will Kinase Inhibitors Make it as Glioblastoma Drugs?
  • Ingo K. Mellinghoff, Nikolaus Schultz, Paul S. Mischel
  • Predictive Genomic Biomarkers
  • Rakesh Kumar, Rafael G. Amado
  • Setting up a Kinase Discovery and Development Project
  • Epigenetic Biomarkers
  • Timothy A. Chan, Stephen B. Baylin
  • Adjuvant Trials of Targeted Agents: The Newest Battleground in the War on Cancer
  • Robert L. Cohen
  • Gideon Bollag
  • Drug Efficacy Testing in Mice
  • William Y. Kim, Norman E. Sharpless
  • Gastrointestinal Stromal Tumors
  • Cristina Antonescu
  • EGFR Mutant Lung Cancer
  • Yixuan Gong, William Pao
Dimensions
unknown
Extent
1 online resource (x, 234 p.)
File format
multiple file formats
Form of item
  • online
  • electronic
Isbn
9783642282966
Level of compression
uncompressed
Other physical details
ill.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (OCoLC)821823527
  • (OCoLC)ocn821823527
Label
Therapeutic kinase inhibitors, Ingo K. Mellinghoff, Charles L. Sawyers, editors ; responsible series editor: Peter K. Vogt, (electronic resource)
Publication
Antecedent source
mixed
Bibliography note
Includes bibliographical references and index
Color
not applicable
Contents
  • Targeting Oncogenic BRAF in Human Cancer
  • Christine A. Pratilas, Feng Xing, David B. Solit
  • Beyond BRAF in Melanoma
  • Adil Daud, Boris C. Bastian
  • JAK-Mutant Myeloproliferative Neoplasms
  • Ross L. Levine
  • Will Kinase Inhibitors Make it as Glioblastoma Drugs?
  • Ingo K. Mellinghoff, Nikolaus Schultz, Paul S. Mischel
  • Predictive Genomic Biomarkers
  • Rakesh Kumar, Rafael G. Amado
  • Setting up a Kinase Discovery and Development Project
  • Epigenetic Biomarkers
  • Timothy A. Chan, Stephen B. Baylin
  • Adjuvant Trials of Targeted Agents: The Newest Battleground in the War on Cancer
  • Robert L. Cohen
  • Gideon Bollag
  • Drug Efficacy Testing in Mice
  • William Y. Kim, Norman E. Sharpless
  • Gastrointestinal Stromal Tumors
  • Cristina Antonescu
  • EGFR Mutant Lung Cancer
  • Yixuan Gong, William Pao
Dimensions
unknown
Extent
1 online resource (x, 234 p.)
File format
multiple file formats
Form of item
  • online
  • electronic
Isbn
9783642282966
Level of compression
uncompressed
Other physical details
ill.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (OCoLC)821823527
  • (OCoLC)ocn821823527

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