The Resource Total Synthesis of Natural Products with Antimicrobial Activity, by Andrew Giltrap, (electronic resource)

Total Synthesis of Natural Products with Antimicrobial Activity, by Andrew Giltrap, (electronic resource)

Label
Total Synthesis of Natural Products with Antimicrobial Activity
Title
Total Synthesis of Natural Products with Antimicrobial Activity
Statement of responsibility
by Andrew Giltrap
Creator
Contributor
Author
Provider
Subject
Language
eng
Summary
This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) – teixobactin and the skyllamycins – with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients
Member of
http://library.link/vocab/creatorName
Giltrap, Andrew
Image bit depth
0
LC call number
RS400-431
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
SpringerLink
Series statement
Springer Theses, Recognizing Outstanding Ph.D. Research,
http://library.link/vocab/subjectName
  • Chemistry
  • Drug resistance
  • Pharmaceutical chemistry
  • Clinical biochemistry
  • Chemistry
  • Medicinal Chemistry
  • Medical Biochemistry
  • Drug Resistance
Label
Total Synthesis of Natural Products with Antimicrobial Activity, by Andrew Giltrap, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction -- Total Synthesis of Teixobactin -- Synthesis of Deshydroxy Skyllamycins A-C -- Total Synthesis of Skyllamycins A-C -- Experimental
Dimensions
unknown
Extent
XXIV, 268 p. 144 illus., 59 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9789811088063
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-981-10-8806-3
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-981-10-8806-3
Label
Total Synthesis of Natural Products with Antimicrobial Activity, by Andrew Giltrap, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction -- Total Synthesis of Teixobactin -- Synthesis of Deshydroxy Skyllamycins A-C -- Total Synthesis of Skyllamycins A-C -- Experimental
Dimensions
unknown
Extent
XXIV, 268 p. 144 illus., 59 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9789811088063
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-981-10-8806-3
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
(DE-He213)978-981-10-8806-3

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