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The Resource Xenotransplantation : International Policy Issues, Organisation for Economic Co-operation and Development, (electronic resource:)

Xenotransplantation : International Policy Issues, Organisation for Economic Co-operation and Development, (electronic resource:)

Creator
Summary
Over one million people world-wide have benefited from successful tissue and organ transplants and survival rates have dramatically improved. But transplantation has become a victim of its own success. The demand for human organs can no longer be met and deaths of persons on waiting lists have more than doubled since 1988. A number of alternatives have been proposed to fill the gap between the supply and demand of organs and the past few years have seen the development of various approaches derived from recent advances in biotechnology. Among these technologies is xenotransplantation - the transplantation of viable cells, tissues and organs from one animal species to another. Xenotransplantation of cells and tissues has been approved for clinical trials in a number of OECD countries. However, opinions about the risks from these early procedures and whether to proceed any further vary. At the New York 1998 Workshop on "International issues in transplantation biotechnology including the use of non-human cells, tissues and organs", world leaders in the field reported on the state of the art and unmet needs in transplantation, addressing in particular the potential, the risks, the ethics and socio-economic impacts of xenotransplantation. Based on presentations, transcripts of round-table discussions and comments raised at the workshop, this book provides an overview of the field and of current regulatory frameworks and addresses the most pressing international policy considerations on xenotransplantation
Language
  • eng
  • eng
Work
Publication
Extent
1 online resource (116 p. )
Note
Bibliographic Level Mode of Issuance: Monograph
Contents
  • SUMMARY OF POLICY CONSIDERATIONS FROM THE NY’98 WORKSHOP
  • Part I. Transplantation
  • 1. INTERNATIONAL TRANSPLANTATION ISSUES: PROBLEMS AND NEEDS
  • The core of the problem: the shortage of organ donors
  • Can the organ procurement gap be narrowed?
  • 2. IMMUNOLOGICAL HURDLES FOR TRANSPLANTATION
  • Current methods to prevent rejection
  • New immunosuppressive drugs
  • Infections in organ transplant recipients on immunosuppressive treatment
  • 3. NEW APPROACHES TO INDUCE TOLERANCE
  • Inbred miniature swine and cloning
  • Part II. Xenotransplantation
  • 1. A HISTORICAL PERSPECTIVE
  • 2. PIGS AS ORGAN DONORS
  • Science: perspectives and issues
  • Will pig organs be physiologically capable of supporting prolonged human life
  • Infectious risk: What precautions should be taken to avoid the transfer of porcine pathogens?
  • Micro-organisms that pigs may harbour
  • 3. BABOONS AS ORGAN DONORS
  • What is the risk of infectious disease when performing baboon-to-man transplants
  • Part III. International Policy Issues in Xenotransplantation
  • 1. HANDLING THE RISK: THE CHALLENGE OF INTERNATIONAL SURVEILLANCE
  • Notification systems
  • Registry systems
  • Archive systems
  • 2. INTERNATIONAL CO-OPERATION
  • Current developments on national and international draft guidelines on xenotransplantation
  • 3. LESSONS LEARNED IN GENE THERAPY
  • 4. INDUSTRY INVOLVEMENT
  • 5. ECONOMIC ASPECTS
  • 6. SOCIO-LEGAL AND ETHICAL ASPECTS
  • Legal issues
  • Ethical issues
  • Animal welfare and husbandry
  • Public perception
  • Developing countries
  • Patient monitoring
  • CONCLUDING CONSIDERATIONS
  • -What is the actual economic burden to society of diseases where xenotransplantation may have a role?
  • What are the options today to alleviate organ shortage?
  • What are the options today to alleviate the burden of disease where xenotransplantation may have a role?
  • What are the options for treatment derived from recent technological advances?
  • What public health tools are there to reduce or eliminate the risk of transmission of infectious agents?
  • What are the key features of an international framework to detect, identify, monitor, evaluate and manage xenozoonotic risk
  • What can we learn from the international regulatory experience on gene therapy?
  • How can the OECD and other international organisations assist the development of international public health tools?
  • What can we learn about animal welfare and about accessibility, equity and acceptance in the context of xenotransplantation?
  • What are the salient features that prevent the adoption of xenotransplantation?
  • What are the research gaps that must be addressed to move the field forward?
  • Annex I Working Party on Xenografts (of The Nuffield Council on Bioethics): Summary of Recommendations
  • Annex II Article 152 of the Amsterdam Treaty (ex Article 129)
  • Annex III Recommendation of the Council of Europe
  • Annex IV Workshop on Transplantations, Including Xenotransplantations: Proposed Strategy for Developing Research into and Accessibility to these Technologies in Africa and the Third World
  • Annex V Joint OECD-New York Academy of Sciences Workshop Programme
  • Annex VI Steering and Expert Group for the Preparation of the OECD Workshop New York ‘98
  • References
Isbn
9786610034086
Instance
Label
Xenotransplantation : International Policy Issues
Title
Xenotransplantation
Title remainder
International Policy Issues
Statement of responsibility
Organisation for Economic Co-operation and Development
Creator
Subject
Genre
Language
  • eng
  • eng
Summary
Over one million people world-wide have benefited from successful tissue and organ transplants and survival rates have dramatically improved. But transplantation has become a victim of its own success. The demand for human organs can no longer be met and deaths of persons on waiting lists have more than doubled since 1988. A number of alternatives have been proposed to fill the gap between the supply and demand of organs and the past few years have seen the development of various approaches derived from recent advances in biotechnology. Among these technologies is xenotransplantation - the transplantation of viable cells, tissues and organs from one animal species to another. Xenotransplantation of cells and tissues has been approved for clinical trials in a number of OECD countries. However, opinions about the risks from these early procedures and whether to proceed any further vary. At the New York 1998 Workshop on "International issues in transplantation biotechnology including the use of non-human cells, tissues and organs", world leaders in the field reported on the state of the art and unmet needs in transplantation, addressing in particular the potential, the risks, the ethics and socio-economic impacts of xenotransplantation. Based on presentations, transcripts of round-table discussions and comments raised at the workshop, this book provides an overview of the field and of current regulatory frameworks and addresses the most pressing international policy considerations on xenotransplantation
Cataloging source
FR-PaOEC
Dewey number
362.1/9795
Government publication
international or intergovernmental publication
Illustrations
illustrations
Language note
English
LC call number
QR188.8.X455 1999
Literary form
non fiction
Nature of contents
dictionaries
http://bibfra.me/vocab/lite/organizationName
Organisation for Economic Co-operation and Development.
Series statement
OECD proceedings Xenotransplantation
http://library.link/vocab/subjectName
  • Science and Technology
  • Xenografts
  • Transplantation of organs, tissues, etc
  • Transplantation immunology
  • Artiodactyla
  • Health Care Evaluation Mechanisms
  • Social Control Policies
  • Technology, Industry, and Agriculture
  • Infection
  • Transplantation
  • Investigative Techniques
  • Probability
  • Epidemiologic Methods
  • Mammals
  • Outcome Assessment (Health Care)
  • Social Sciences
  • Mathematics
  • Animal Population Groups
  • Health Care Economics and Organizations
  • Environment and Public Health
  • Eukaryota
  • Sociology
  • Health Services
  • Health
  • Culture
  • Research
  • Medicine
  • Art
  • Persons
  • Prognosis
  • Biomedical Research
  • Organisms, Genetically Modified
  • Natural Science Disciplines
  • Technology, Industry, Agriculture
  • Organism Forms
  • Named Groups
  • Health Occupations
  • Science
  • Analytical, Diagnostic and Therapeutic Techniques and Equipment
  • Quality of Health Care
  • Diagnosis
  • Policy
  • Health Care
  • Anthropology, Education, Sociology and Social Phenomena
  • Mathematical Concepts
  • Health Care Facilities, Manpower, and Services
  • Population Characteristics
  • Humanities
  • Outcome and Process Assessment (Health Care)
  • Organisms
  • Vertebrates
  • Surgical Procedures, Operative
  • Anthropology, Cultural
  • Bacterial Infections and Mycoses
  • Phenomena and Processes
  • Disciplines and Occupations
  • Anthropology
  • Health Care Quality, Access, and Evaluation
  • Diseases
  • Chordata
  • Health Services Administration
  • Animal Welfare
  • Animals, Genetically Modified
  • Primates
  • Swine
  • Public Policy
  • Economics
  • Human Body
  • Public Health
  • Risk
  • Statistics as Topic
  • Animal Experimentation
  • Developing Countries
  • Transplantation, Heterologous
  • Human Experimentation
  • International Cooperation
  • Animals
  • Social Control, Formal
  • Tissue Donors
  • Treatment Outcome
  • Internationality
  • Tissue and Organ Procurement
  • Industry
  • Organ Transplantation
  • Communicable Diseases
  • Biology
  • Health & Biological Sciences
  • Microbiology & Immunology
Label
Xenotransplantation : International Policy Issues, Organisation for Economic Co-operation and Development, (electronic resource:)
Instantiates
Publication
Note
Bibliographic Level Mode of Issuance: Monograph
Antecedent source
not applicable
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
SUMMARY OF POLICY CONSIDERATIONS FROM THE NY’98 WORKSHOP -- Part I. Transplantation -- 1. INTERNATIONAL TRANSPLANTATION ISSUES: PROBLEMS AND NEEDS -- The core of the problem: the shortage of organ donors -- Can the organ procurement gap be narrowed? -- 2. IMMUNOLOGICAL HURDLES FOR TRANSPLANTATION -- Current methods to prevent rejection -- New immunosuppressive drugs -- Infections in organ transplant recipients on immunosuppressive treatment -- 3. NEW APPROACHES TO INDUCE TOLERANCE -- Inbred miniature swine and cloning -- Part II. Xenotransplantation -- 1. A HISTORICAL PERSPECTIVE -- 2. PIGS AS ORGAN DONORS -- Science: perspectives and issues -- Will pig organs be physiologically capable of supporting prolonged human life -- Infectious risk: What precautions should be taken to avoid the transfer of porcine pathogens? -- Micro-organisms that pigs may harbour -- 3. BABOONS AS ORGAN DONORS -- What is the risk of infectious disease when performing baboon-to-man transplants -- Part III. International Policy Issues in Xenotransplantation -- 1. HANDLING THE RISK: THE CHALLENGE OF INTERNATIONAL SURVEILLANCE -- Notification systems -- Registry systems -- Archive systems -- 2. INTERNATIONAL CO-OPERATION -- Current developments on national and international draft guidelines on xenotransplantation -- 3. LESSONS LEARNED IN GENE THERAPY -- 4. INDUSTRY INVOLVEMENT -- 5. ECONOMIC ASPECTS -- 6. SOCIO-LEGAL AND ETHICAL ASPECTS -- Legal issues -- Ethical issues -- Animal welfare and husbandry -- Public perception -- Developing countries -- Patient monitoring -- CONCLUDING CONSIDERATIONS -- -What is the actual economic burden to society of diseases where xenotransplantation may have a role? -- What are the options today to alleviate organ shortage? -- What are the options today to alleviate the burden of disease where xenotransplantation may have a role? -- What are the options for treatment derived from recent technological advances? -- What public health tools are there to reduce or eliminate the risk of transmission of infectious agents? -- What are the key features of an international framework to detect, identify, monitor, evaluate and manage xenozoonotic risk -- What can we learn from the international regulatory experience on gene therapy? -- How can the OECD and other international organisations assist the development of international public health tools? -- What can we learn about animal welfare and about accessibility, equity and acceptance in the context of xenotransplantation? -- What are the salient features that prevent the adoption of xenotransplantation? -- What are the research gaps that must be addressed to move the field forward? -- Annex I Working Party on Xenografts (of The Nuffield Council on Bioethics): Summary of Recommendations -- Annex II Article 152 of the Amsterdam Treaty (ex Article 129) -- Annex III Recommendation of the Council of Europe -- Annex IV Workshop on Transplantations, Including Xenotransplantations: Proposed Strategy for Developing Research into and Accessibility to these Technologies in Africa and the Third World -- Annex V Joint OECD-New York Academy of Sciences Workshop Programme -- Annex VI Steering and Expert Group for the Preparation of the OECD Workshop New York ‘98 -- References
Extent
1 online resource (116 p. )
File format
multiple file formats
Form of item
online
Isbn
9786610034086
Media category
computer
Media type code
  • c
Other control number
10.1787/9789264172654-en
Other physical details
ill..
Specific material designation
remote
System control number
  • (FR-PaOEC)9789264172654-en
  • (SSID)ssj0000092571
  • (PQKBManifestationID)11126968
  • (PQKBTitleCode)TC0000092571
  • (PQKBWorkID)10014544
  • (PQKB)11730244
  • (EXLCZ)99111093034088044
Label
Xenotransplantation : International Policy Issues, Organisation for Economic Co-operation and Development, (electronic resource:)
Publication
Note
Bibliographic Level Mode of Issuance: Monograph
Antecedent source
not applicable
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
SUMMARY OF POLICY CONSIDERATIONS FROM THE NY’98 WORKSHOP -- Part I. Transplantation -- 1. INTERNATIONAL TRANSPLANTATION ISSUES: PROBLEMS AND NEEDS -- The core of the problem: the shortage of organ donors -- Can the organ procurement gap be narrowed? -- 2. IMMUNOLOGICAL HURDLES FOR TRANSPLANTATION -- Current methods to prevent rejection -- New immunosuppressive drugs -- Infections in organ transplant recipients on immunosuppressive treatment -- 3. NEW APPROACHES TO INDUCE TOLERANCE -- Inbred miniature swine and cloning -- Part II. Xenotransplantation -- 1. A HISTORICAL PERSPECTIVE -- 2. PIGS AS ORGAN DONORS -- Science: perspectives and issues -- Will pig organs be physiologically capable of supporting prolonged human life -- Infectious risk: What precautions should be taken to avoid the transfer of porcine pathogens? -- Micro-organisms that pigs may harbour -- 3. BABOONS AS ORGAN DONORS -- What is the risk of infectious disease when performing baboon-to-man transplants -- Part III. International Policy Issues in Xenotransplantation -- 1. HANDLING THE RISK: THE CHALLENGE OF INTERNATIONAL SURVEILLANCE -- Notification systems -- Registry systems -- Archive systems -- 2. INTERNATIONAL CO-OPERATION -- Current developments on national and international draft guidelines on xenotransplantation -- 3. LESSONS LEARNED IN GENE THERAPY -- 4. INDUSTRY INVOLVEMENT -- 5. ECONOMIC ASPECTS -- 6. SOCIO-LEGAL AND ETHICAL ASPECTS -- Legal issues -- Ethical issues -- Animal welfare and husbandry -- Public perception -- Developing countries -- Patient monitoring -- CONCLUDING CONSIDERATIONS -- -What is the actual economic burden to society of diseases where xenotransplantation may have a role? -- What are the options today to alleviate organ shortage? -- What are the options today to alleviate the burden of disease where xenotransplantation may have a role? -- What are the options for treatment derived from recent technological advances? -- What public health tools are there to reduce or eliminate the risk of transmission of infectious agents? -- What are the key features of an international framework to detect, identify, monitor, evaluate and manage xenozoonotic risk -- What can we learn from the international regulatory experience on gene therapy? -- How can the OECD and other international organisations assist the development of international public health tools? -- What can we learn about animal welfare and about accessibility, equity and acceptance in the context of xenotransplantation? -- What are the salient features that prevent the adoption of xenotransplantation? -- What are the research gaps that must be addressed to move the field forward? -- Annex I Working Party on Xenografts (of The Nuffield Council on Bioethics): Summary of Recommendations -- Annex II Article 152 of the Amsterdam Treaty (ex Article 129) -- Annex III Recommendation of the Council of Europe -- Annex IV Workshop on Transplantations, Including Xenotransplantations: Proposed Strategy for Developing Research into and Accessibility to these Technologies in Africa and the Third World -- Annex V Joint OECD-New York Academy of Sciences Workshop Programme -- Annex VI Steering and Expert Group for the Preparation of the OECD Workshop New York ‘98 -- References
Extent
1 online resource (116 p. )
File format
multiple file formats
Form of item
online
Isbn
9786610034086
Media category
computer
Media type code
  • c
Other control number
10.1787/9789264172654-en
Other physical details
ill..
Specific material designation
remote
System control number
  • (FR-PaOEC)9789264172654-en
  • (SSID)ssj0000092571
  • (PQKBManifestationID)11126968
  • (PQKBTitleCode)TC0000092571
  • (PQKBWorkID)10014544
  • (PQKB)11730244
  • (EXLCZ)99111093034088044

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